Results 51 to 60 of about 919,214 (288)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
SystemsProblem: Predicting dependency relationships in nonequilibrium systems is a critical challenge in complex systems research. Solution proposed: In this paper, we propose a novel method for predicting dependent edges in network models of nonequilibrium ...
Qingyu Zou +3 more
doaj +1 more source
Pre-Trained Bidirectional Temporal Representation for Crowd Flows Prediction in Regular Region
IEEE Access, 2019 Deep learning-based methods for predicting spatial-temporal data such as crowd flows need to consider both spatial dependency and temporal dependency. Previous research mainly focused on modeling spatial dependency, whereas studies on temporal dependency
Wenying Duan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Self-verified extension of affine arithmetic to arbitrary order
Le Matematiche, 2008 Affine Arithmetic (AA) is a self-verifying computational approach that keeps track of first-order correlation between uncertainties in the data and intermediate and final results.In this paper we propose a higher-order extension satisfying the requirements ...
Giuseppe Bilotta
doaj
Sequence Alignment Ensemble With a Single Neural Network for Sequence Labeling
IEEE Access, 2022 Sequence labeling, in which a class or label is assigned to each token in a given input order, is a fundamental task in natural language processing. Many advanced neural network architectures have recently been proposed to solve the sequential labeling ...
Jeesu Jung +4 more
doaj +1 more source
A Linear Programming Approach to Sequential Hypothesis Testing
, 2015 Under some mild Markov assumptions it is shown that the problem of designing optimal sequential tests for two simple hypotheses can be formulated as a linear program.
Fauss, Michael, Zoubir, Abdelhak M.
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Feature dependence graph based source code loophole detection method
Tongxin xuebao, 2023 Given the problem that the existing source code loophole detection methods did not explicitly maintain the semantic information related to the loophole in the source code, which led to the difficulty of feature extraction of loo-phole statements and the ...
Hongyu YANG +3 more
doaj +2 more sources