Results 91 to 100 of about 496,317 (234)

Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein

The FEBS Journal, EarlyView.
An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj, Tadeja Bele, Anastasija Panevska, Gregor Bajc, Jan Kejžar, Miha Bahun, Nataša Poklar Ulrih, Valentina Levak, Matej Skočaj, Larisa Lara Popošek, Peter Veranič, Nataša Resnik, Kristina Sepčić   +12 more
wiley   +1 more source

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, EarlyView.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Districting in last‐mile delivery with stochastic customers

International Transactions in Operational Research, EarlyView.
Abstract Due to the peculiarities of city streets, last‐mile logistics is typically organized using territory‐based routing approaches, which divide the city into a set of districts and assign drivers to deliver in one or more of them. This allows drivers to develop a deep understanding of the characteristics of each district, and clients benefit from ...
Maria Elena Bruni, Edoardo Fadda, Stanislav Fedorov, Guido Perboli   +3 more
wiley   +1 more source

Development and Validation of a New Prediction Criteria for Neoadjuvant Chemotherapy Response in Locally Advanced Gastric Cancer Based on Ferroptosis‐Related Biomarkers

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background The efficacy of neoadjuvant chemotherapy (NAC) combined with surgery and postoperative adjuvant chemotherapy in improving the prognosis of locally advanced gastric cancer (LAGC) has been confirmed. Nevertheless, there is still no effective tool to predict the response to NAC in gastric cancer patients.
Minxuan Shen, Qinbo Cai, Rongchang Wang, Feiran Zhang, Huanjie Chen, Xiaoqun Wang, Rongman Xie, Jie Zhang, Baoyi Liu, Yulong He, Xun Hou, Dongjie Yang   +11 more
wiley   +1 more source

An AI‐Supported Pedagogical Architecture to Foster Self‐Regulated Learning in Virtual Environments

Computer Applications in Engineering Education, Volume 34, Issue 1, January 2026.
ABSTRACT This study reports on the design, implementation, and evaluation of an AI‐Supported Pedagogical Architecture (PA) aimed at fostering Self‐Regulated Learning (SRL) within a Virtual Learning Environment (VLE). The architecture was integrated into the Moodle platform and applied in an introductory Python course.
Geycy Dyany O. Lima, Juliete A. R. Costa, Fabiano A. Dorça, Rafael D. Araújo   +3 more
wiley   +1 more source

Data Dependency-Aware Code Generation from Enhanced UML Sequence Diagrams [PDF]

Wenxin Mao, Zhitao Wang, Long Wang, Sirong Chen, Cuiyun Gao, Luyang Cao, Ziming Liu, Qiming Zhang, Jun Zhou, Zhi Jin   +9 more
openalex   +1 more source

A Farm‐To‐Fork Framework to Assess the Scope and Limitations of Agricultural Data Structures

Modern Agriculture, Volume 3, Issue 2, December 2025.
The diagram illustrates the agricultural data structures evaluation process using AgrIMAF. The data structures were gathered from the literature and ranged from data models and conceptual frameworks to file‐based systems and databases. They are then systematically analysed through the AgrIMAF structure, which consists of three layers, that is, the ...
Cheikh M. M. Thiaw, Louis R. E. Asie, Herlest B. Lovince, Alain N. Rousseau, Paul Celicourt   +4 more
wiley   +1 more source

A human-in-the-loop based Bayesian network approach to improve imbalanced radiation outcomes prediction for hepatocellular cancer patients with stereotactic body radiotherapy. [PDF]

Front Oncol, 2022
Luo Y, Cuneo KC, Lawrence TS, Matuszak MM, Dawson LA, Niraula D, Ten Haken RK, El Naqa I.   +7 more
europepmc   +1 more source