Results 101 to 110 of about 496,317 (234)
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, Volume 599, Issue 21, Page 3103-3112, November 2025.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Intelligent Decision-Support System for Epidemiological Diagnostics. II. Information Technologies Development*, *. [PDF]
Cybern Syst Anal, 2022 Bazilevych KO +4 more
europepmc +1 more source
FEBS Letters, Volume 599, Issue 21, Page 3113-3123, November 2025.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
Toward an idiomatic framework for cognitive robotics. [PDF]
Patterns (N Y), 2022 Damgaard MR, Pedersen R, Bak T.
europepmc +1 more source
FEBS Letters, Volume 599, Issue 21, Page 3047-3065, November 2025.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 11, Page 3409-3426, November 2025.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Shape Expressions (ShEx) schemas for the FHIR R5 specification. [PDF]
J Biomed Inform, 2023 Sharma DK +4 more
europepmc +1 more source
FEBS Open Bio, Volume 15, Issue 11, Page 1771-1788, November 2025.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
wiley +1 more source
Preface - 22nd Brazilian Symposium on Formal Methods - SBMF 2019. [PDF]
Sci Comput Program, 2021 Duran A, Wadler P.
europepmc +1 more source