Results 111 to 120 of about 496,317 (234)

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, Volume 15, Issue 11, Page 1900-1912, November 2025.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Formalized aspect-oriented misuse case for specifying crosscutting security threats and mitigations. [PDF]

PLoS One
Iqbal S, Faiz RB, Usman M, Rehman SU.
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, Volume 15, Issue 11, Page 1886-1899, November 2025.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Determining structures of RNA conformers using AFM and deep neural networks. [PDF]

Nature
Degenhardt MFS, Degenhardt HF, Bhandari YR, Lee YT, Ding J, Yu P, Heinz WF, Stagno JR, Schwieters CD, Watts NR, Wingfield PT, Rein A, Zhang J, Wang YX.   +13 more
europepmc   +1 more source

Extraction of use case diagram elements using natural language processing and network science. [PDF]

PLoS One, 2023
Imtiaz Malik M, Azam Sindhu M, Ayaz Abbasi R.   +2 more
europepmc   +1 more source

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, Volume 15, Issue 11, Page 1814-1826, November 2025.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

Advancing Hyperspectral Image Analysis with CTNet: An Approach with the Fusion of Spatial and Spectral Features. [PDF]

Sensors (Basel)
Yadav DP, Kumar D, Jalal AS, Sharma B, Webber JL, Mehbodniya A.   +5 more
europepmc   +1 more source

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

Advanced Science, Volume 12, Issue 44, November 27, 2025.
This work found that early‐stage insulin sensitization but late‐stage insulin resistance in prenatal caffeine exposure (PCE)‐ induced intrauterine growth restriction (IUGR) offspring may be related to the hepatic AGEs accumulation via intrauterine GR/miR‐1224 programming by glucocorticoids.
Yongguo Dai, Xiaoling Guo, Pengxia Yu, Dingmei Zhang, Hao Kou, Hui Wang   +5 more
wiley   +1 more source

Report from MDE practice: An interview-based evaluation of model-driven engineering uses. [PDF]

PLoS One
Alfraihi H, Lano K.
europepmc   +1 more source

Automated UML Visualization of Software Ecosystems: Tracking Versions, Dependencies, and Security Updates

Vladimir Kan, Mathangi LNU, Solomon Berhe, Chandrakala Kari, Marc Maynard, Foutse Khomh   +5 more
openalex   +1 more source