Results 141 to 150 of about 496,317 (234)

Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5517-5535, November 2025.
Abstract Background and Purpose Hepatocellular carcinoma (HCC), the third leading cause of cancer‐related deaths worldwide, has limited treatment options and high mortality rate. We previously used a bioinformatics approach to identify niclosamide (NIC) as a promising repurposed drug candidate for HCC.
Mingdian Tan, Wei Ye, Yi Liu, Xiaowu Chen, Lakshmi Huttad, Mei‐Sze Chua, Samuel So   +6 more
wiley   +1 more source

A DEVS-based engine for building digital quadruplets. [PDF]

Simulation, 2021
Niyonkuru D, Wainer G.
europepmc   +1 more source

Human tissue kallikrein 14 induces the expression of IL‐6, IL‐8, and CXCL1 in skin fibroblasts through protease‐activated receptor 1 signaling

The FEBS Journal, Volume 292, Issue 21, Page 5659-5675, November 2025.
Human tissue kallikrein 14 (KLK14), a skin protease, may mediate paracrine signaling in wound healing. KLK14 released by epithelial cells activates fibroblasts via PAR‐1 activation, inducing IL‐6, IL‐8, and CXCL1 expression. These cytokines in turn promote keratinocyte proliferation and migration, resulting in wound closure.
Laura Sasiadek, Ewa Bielecka, Katherine Falkowski, Magdalena Kulczycka, Grzegorz Bereta, Anna Maksylewicz, Natalia Zubrzycka, Ewelina Dobosz, Joanna Kozieł, Justyna Drukała, Maciej Lech, Natalia Horbach, Marcin Poręba, Klaudia Brix, Grzegorz Dubin, Jan Potempa, Tomasz Kantyka   +16 more
wiley   +1 more source

Underlying Geometric Flow in Hamiltonian Evolution. [PDF]

Entropy (Basel)
Elgressy G, Horwitz L.
europepmc   +1 more source

Intensifying the search-based optimization of product line architectures with crossover operators. [PDF]

Empir Softw Eng, 2022
da Silva DF, Okada LF, Assunção WKG, Colanzi TE.   +3 more
europepmc   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, Volume 292, Issue 21, Page 5697-5722, November 2025.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. However, reliable reagents for H antigen detection are lacking. We generated two novel monoclonal antibodies using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, that specifically detect the H antigen on glycan microarrays, glycoproteins, and ...
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Design of an iterative adaptive method for volatility-aware test case prioritization in rapidly evolving software systems. [PDF]

MethodsX
Rao KS, Rao AA, Raju PR.
europepmc   +1 more source

A model-driven framework to support strategic agility: Value-added perspective. [PDF]

Inf Softw Technol, 2022
Tsilionis K, Wautelet Y.
europepmc   +1 more source

Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen

The FEBS Journal, Volume 292, Issue 22, Page 6100-6116, November 2025.
We investigated the role of the signal regulatory protein alpha (SIRPα)/CD47 axis in phagocytosis by disrupting the SIRPA gene in the THP‐1 cell line. The SIRPα KO THP‐1 cells retained their monocyte and macrophage characteristics similar to their wild‐type (WT) counterparts.
Saitong Muneekaew, Pasut Sasithong, Koollawat Chupradit, Kritayaporn Saiprayong, Thunchanok Nuchphongsai, Methichit Wattanapanitch   +5 more
wiley   +1 more source

Control of a Drone in Virtual Reality Using MEMS Sensor Technology and Machine Learning. [PDF]

Micromachines (Basel), 2022
Covaciu F, Iordan AE.
europepmc   +1 more source