Results 61 to 70 of about 496,317 (234)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

open access: yesAdvanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong   +22 more
wiley   +1 more source

From ternary relationship to relational tables: a case against common beliefs [PDF]

open access: yes, 2002
The transformation from n-ary relationships to a relational database schema has never been really fully analyzed. This paper presents one of the several ternary cases ignored by the ER-to-RM literature.
Camps Pare, Rafael
core   +1 more source

Development of an Interaction Model of the Protein–Nanocluster Interface by Machine Learning–Assisted Clustering of Amino Acids

open access: yesAggregate, EarlyView.
An interaction model for the interface between ligand‐protected gold nanoclusters and proteins is developed using unsupervised machine learning techniques and validated by molecular dynamics simulations and density functional theory calculations. ABSTRACT The interactions that occur in the interface of proteins and ligand‐stabilised metal nanoclusters ...
Brenda Ferrari   +3 more
wiley   +1 more source

A Framework for Evaluating Model-Driven Self-adaptive Software Systems [PDF]

open access: yes, 2019
In the last few years, Model Driven Development (MDD), Component-based Software Development (CBSD), and context-oriented software have become interesting alternatives for the design and construction of self-adaptive software systems.
Magableh, Basel
core   +2 more sources

Semantic primitives and compositionality: An Annual Review of Information Science and Technology (ARIST) paper

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract The term semantic primitives refers to a set of basic, atomic concepts from which all other (compound) concepts are constructed. It presupposes the principle of compositionality—the idea that complex items or expressions can be formed by combining simpler constituents.
Birger Hjørland
wiley   +1 more source

Modeling the object-oriented software process: OPEN and the unified process [PDF]

open access: yes, 1999
A short introduction to software process modeling is presented, particularly object-oriented modeling. Two major industrial process models are discussed: the OPEN model and the Unified Process model.
Aksit, Mehmet   +2 more
core   +1 more source

Late‐onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi‐center prospective longitudinal observational study (ELUCID)

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Late‐onset unexplained epilepsy (LoUE), defined as epilepsy onset after age 55 without an obvious cause, is an important risk factor for dementia. Studies have shown that 10%–25% of individuals with LoUE develop dementia within 3–4 years following their first seizure.
Alice D. Lam   +13 more
wiley   +1 more source

Safety Considerations in Deployment of Robotic Systems – A Systematic Review

open access: yesJournal of Field Robotics, EarlyView.
ABSTRACT An in‐depth understanding of the risks related to robotic systems is crucial to guarantee safety throughout all stages of robot design and operations. This required a thorough risk assessment following international standards. This study presents a systematic review of previous research on safety considerations in the design of robotic systems,
Adedire D. Adesiji   +6 more
wiley   +1 more source

Refinement of SDBC Business Process Models Using ISDL [PDF]

open access: yes, 2006
Aiming at aligning business process modeling and software specification, the SDBC approach considers a multi-viewpoint modeling where static, dynamic, and data business process aspect models have to be mapped adequately to corresponding static, dynamic ...
Quartel, Dick, Shishkov, Boris
core   +1 more source

Extracting Formal Models from Normative Texts

open access: yes, 2016
We are concerned with the analysis of normative texts - documents based on the deontic notions of obligation, permission, and prohibition. Our goal is to make queries about these notions and verify that a text satisfies certain properties concerning ...
Camilleri, John J.   +2 more
core   +2 more sources

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