Results 71 to 80 of about 496,317 (234)

MBSE Co‐Pilot: A Research Roadmap

open access: yesSystems Engineering, EarlyView.
ABSTRACT As the complexity of engineered systems continues to increase, Model‐Based Systems Engineering (MBSE) methodologies, languages, and tools are increasingly insufficient to meet the demands of modern systems engineering. This paper proposes a research roadmap for the development of an AI‐driven machine, referred to as MBSE Co‐Pilot, designed to ...
Wenheng Zhang   +6 more
wiley   +1 more source

Addressing Complexity in System of Systems With GraphRAG: An AI‐Driven Framework for Dynamic Data Integration

open access: yesSystems Engineering, EarlyView.
ABSTRACT System of Systems (SoS) environments are inherently complex, involving numerous operationally and managerially independent component systems with hidden interdependencies and frequent interactions based on unstructured data. In this paper, we propose using graphical Retrieval‐Augmented Generation (GraphRAG), a tool that combines large language
Yinchien Huang   +2 more
wiley   +1 more source

XML document design via GN-DTD [PDF]

open access: yes, 2010
Designing a well-structured XML document is important for the sake of readability and maintainability. More importantly, this will avoid data redundancies and update anomalies when maintaining a large quantity of XML based documents.
Wang, Bing, Zainol, Zurinahni
core  

Identification of Missing Knowledge in MBSE System Models Using Graph‐Based Machine Learning

open access: yesSystems Engineering, EarlyView.
ABSTRACT The design and development of complex aerospace systems pose significant challenges due to their growing complexity. Iterative design processes, guided by formal specifications, strive to refine initially vague characteristics through multiple stages.
Esma Karagoz   +2 more
wiley   +1 more source

Can unsupervised machine learning gain new insights into urodynamic pressure flow pattern analysis?

open access: yesBJU International, EarlyView.
Objectives To explore the use of unsupervised machine learning (UML) to analyse segments of the pressure flow study (PFS) curve after maximum flow, and subsequently to analyse the urodynamic and patient characteristics of men in the detected clusters. Subjects and Methods In this study, we considered 1650 PFSs of men with lower urinary tract symptoms ...
Wouter van Dort   +4 more
wiley   +1 more source

Semantics Through Pictures: towards a diagrammatic semantics for object-oriented modelling notations [PDF]

open access: yes, 1997
An object-oriented (OO) model has a static component, the set of allowable snapshots or system states, and a dynamic component, the set of filmstrips or sequences of snapshots.
Civello, Franco   +4 more
core   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

Statechart Slicing [PDF]

open access: yes, 2009
The paper discusses how to reduce a statechart model by slicing. We start with the discussion of control dependencies and data dependencies in statecharts.
Fox, C, Luangsodsai, A
core  

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy   +16 more
wiley   +1 more source

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