Results 81 to 90 of about 496,317 (234)
Entropy as a Measure of Consistency in Software Architecture. [PDF]
Entropy (Basel), 2023 Niepostyn SJ, Daszczuk WB.
europepmc +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, EarlyView.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
The FEBS Journal, EarlyView.Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano +9 more
wiley +1 more source
The FEBS Journal, EarlyView.Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz +8 more
wiley +1 more source
MedicaidJS: a FAIR approach to real-time drug analytics. [PDF]
Bioinform Adv, 2023 Agarwal K +3 more
europepmc +1 more source
The FEBS Journal, EarlyView.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
A Framework for Cybersecurity Requirements Management in the Automotive Domain. [PDF]
Sensors (Basel), 2023 Luo F, Jiang Y, Wang J, Li Z, Zhang X.
europepmc +1 more source
TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation
The FEBS Journal, EarlyView.TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni +7 more
wiley +1 more source
The FEBS Journal, EarlyView.The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini +6 more
wiley +1 more source