Results 51 to 60 of about 243,308 (306)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

DEVELOPMENT OF DEPOSITS GUARANTEE IN THE BANKING SYSTEM OF MOLDOVA [PDF]

open access: yesAnnals of the University of Craiova: Economic Sciences Series, 2017
Money kept in house versus money deposited in the bank is a dilemma arising primarily out of fear of losing. To mitigate these risks and to enhance confidence in the banking system, the authorities propose to increas the deposit guarantee ceiling ...
Larisa Mistrean
doaj  

Evaluation of the effectiveness of the Bank Guarantee Fund's deposit guarantee activities

open access: yesCatallaxy, 2023
Motivation: The Bank Guarantee Fund (BFG) operates by following two formulas, one of which is the implementation of the disbursement of guaranteed amounts. The BFG has been changing the limits of the guaranteed amounts, streamlining and improving the way in which the disbursements are made, as well as conducting information activities.
openaire   +1 more source

Deposit insurance suitable for Europe: Proposal for a three-stage deposit guarantee scheme with limited European liability [PDF]

open access: yes, 2013
In this note, a new concept for a European deposit guarantee scheme is proposed, which takes account of the strong political reservations against a mutualization of the liability for bank deposits.
Krahnen, Jan Pieter
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

ORGANIZATIONAL MODEL OF POLISH COOPERATIVE BANKS IN THE POST-CRISIS REGULATORY ENVIRONMENT

open access: yesФінансово-кредитна діяльність: проблеми теорії та практики, 2018
Even though the Polish cooperative banks were affected by the global crisis only indirectly, yet after the crisis their condition has begun to deteriorate.
A. Jurkowska
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

LEGAL PROTECTION AGAINST DEPOSITORS' CUSTOMERS WITH MUDHARABAH CONTRACT ON ISLAMIC BANKS

open access: yesJurnal Pembaharuan Hukum, 2019
Deposit type most often used by Islamic Bank in collecting funds from the public is revshare system (mudharabah) where the customer is acting as an investor and profit from business carried on by the bank.
Elvira Fitriyani Pakpahan
doaj   +1 more source

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