Results 21 to 30 of about 1,788,838 (315)

The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder

European Psychiatry, 2022
Introduction In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD).
M. Kucuker, A. Ozerdem, D. Ceylan, A. Cabello-Arreola, M.C. Ho, B. Joseph, L. Webb, P. Croarkin, M. Frye, M. Veldic   +9 more
doaj   +1 more source

A pilot trial of quetiapine, lithium, or placebo added to divalproex sodium for hypomanic or manic episodes in ambulatory adults with bipolar I disorder

International Journal of Bipolar Disorders, 2022
Background Many patients with bipolar I disorder do not respond to monotherapy treatment with mood-stabilizing medications, and combination regimens are commonly used in both inpatient and outpatient settings for the acute and maintenance treatment of ...
Victoria E. Cosgrove, Santiago Allende, Iola Gwizdowski, E. Grace Fischer, Michael Ostacher, Trisha Suppes   +5 more
doaj   +1 more source

Exercise for depression [PDF]

, 2008
Background Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychotherapy, but some people may prefer alternative approaches such as exercise.
McMurdo, Marion, Greig, Carolyn; id_orcid, Greig, Carolyn A., Marion McMurdo, Morley, Wendy, McMurdo, Marion E.T., Paul Campbell, Mead, Gillian E., Gillian E Mead, Wendy Morley, Lawlor, Debbie A., Debbie A Lawlor, Campbell, Paul, Carolyn A Greig   +13 more
core   +1 more source

Genome-wide transcriptomics of the amygdala reveals similar oligodendrocyte-related responses to acute and chronic alcohol drinking in female mice

Translational Psychiatry, 2022
Repeated excessive alcohol consumption is a risk factor for alcohol use disorder (AUD). Although AUD has been more common in men than women, women develop more severe behavioral and physical impairments. However, relatively few new therapeutics targeting
Sharvari Narendra, Claudia Klengel, Bilal Hamzeh, Drasti Patel, Joy Otten, Roy Lardenoije, Emily L. Newman, Klaus A. Miczek, Torsten Klengel, Kerry J. Ressler, Junghyup Suh   +10 more
doaj   +1 more source

Depression [PDF]

, 2023
Depression is a mood condition that is the second largest cause of disability globally. This chapter describes the characteristics and associated features of depression.
Brown, James, Beel, Nathan
core  

Redefining post-stress depression as a spatiotemporal five-disease multimorbidity trajectory: ghrelin-driven anchoring by Shugan absorbed compounds [PDF]

Exploration of Neuroprotective Therapy
Aim: This study aimed to redefine post-stress depressive pathogenesis through a novel five-disease multimorbidity trajectory model (brain1-coronary-brain2-gastro-enteric; B1CB2GE) and to evaluate the multifunctional anchoring effects of Bupleurum ...
Xi Huang, Runze Zhou, Chendong Xu, Haotian Qian, Yunke Huang, Zhan Gao, Qiulong Zhao, Min Xu, Shaoqi Shi, Ailing Yu, Jialing Zhou, Yaling Liu, Chenxiao Shan, Ping Ren   +13 more
doaj   +1 more source

Efficacy of an internet-based self-management intervention for depression or dysthymia – a study protocol of an RCT using an active control condition

BMC Psychiatry, 2019
Background The treatment of major depressive disorder, a highly prevalent disorder associated with pronounced burden, is a large challenge to healthcare systems worldwide.
Caroline Oehler, Frauke Görges, Daniel Böttger, Juliane Hug, Nicole Koburger, Elisabeth Kohls, Christine Rummel-Kluge   +6 more
doaj   +1 more source

Change processes in cognitive behavioral therapy and motivational interviewing for depression and heavy alcohol use: A network approach

Journal of Affective Disorders Reports, 2021
Objective: Both cognitive behavioral therapy for depression (CBT-D) combined with brief motivational interviewing (CBT-D+BMI) and alone are associated with symptom improvement among college students with co-occurring depression and heavy episodic ...
Joshua E. Curtiss, Bridget Wallace, Lauren B. Fisher, Maren Nyer, Felipe Jain, Cristina Cusin, Paola Pedrelli   +6 more
doaj   +1 more source

Arabic-language digital interventions for depression in German routine health care are acceptable, but intervention adoption remains a challenge

Scientific Reports
Migrants face many barriers to mental health care, such as different cultural concepts of distress, unfamiliar pathways to care, and language. Digital mental health interventions are effective and scalable in multi-language versions.
Hanna Reich, Ulrich Hegerl, Anja Rosenthal, Caroline Allenhof   +3 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source