Results 141 to 150 of about 786,893 (341)

Non-REM sleep in major depressive disorder

NeuroImage: Clinical, 2022
Disturbed sleep is a key symptom in major depressive disorder (MDD). REM sleep alterations are well described in the current literature, but little is known about non-REM sleep alterations.
Leonore Bovy, Frederik D. Weber, Indira Tendolkar, Guillén Fernández, Michael Czisch, Axel Steiger, Marcel Zeising, Martin Dresler   +7 more
doaj  

Temporal discounting in major depressive disorder. [PDF]

, 2013
BACKGROUND: Major depressive disorder (MDD) is associated with abnormalities in financial reward processing. Previous research suggests that patients with MDD show reduced sensitivity to frequency of financial rewards.
B. J. Sahakian, Chao, E. J. Thomas, E. Pulcu, First, G. Juhasz, I. M. Anderson, J. F. W. Deakin, M. McFarquhar, Mazur, Murphy, Neter, P. D. Trotter, R. Elliott, R. Zahn, Sheehan, Takahashi   +16 more
core   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

A Feasibility Study of Patients with Major Depression and Substance Use Disorders: Vortioxetine as Maintenance Treatment

Neuropsychiatric Disease and Treatment, 2022
Ignacio Basurte-Villamor,1 Pablo Vega,2 Carlos Roncero,3– 5 José Martínez-Raga,6 Lara Grau-López,7– 10 Lourdes Aguilar,3– 5 Marta Torrens,11 Nestor Szerman12 1Department of Psychiatry and Behavioral Health, Clínica López Ibor, Madrid, Spain; 2Institute ...
Basurte-Villamor I, Vega P, Roncero C, Martínez-Raga J, Grau-López L, Aguilar L, Torrens M, Szerman N   +7 more
doaj  

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

Molecular Psychiatry, 2015
The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the ...
L. Schmaal, D. Veltman, T. V. Erp, P. Sämann, T. Frodl, T. Frodl, N. Jahanshad, E. Loehrer, H. Tiemeier, A. Hofman, W. Niessen, W. Niessen, M. Vernooij, M. Ikram, K. Wittfeld, H. Grabe, A. Block, K. Hegenscheid, H. Völzke, D. Hoehn, M. Czisch, J. Lagopoulos, S. Hatton, I. Hickie, R. Goya-Maldonado, B. Krämer, O. Gruber, B. Couvy-Duchesne, B. Couvy-Duchesne, M. Rentería, Lachlan T. Strike, Lachlan T. Strike, Natalie T. Mills, Natalie T. Mills, G. Zubicaray, K. Mcmahon, S. Medland, N. Martin, N. Gillespie, M. Wright, G. Hall, G. MacQueen, Eva-Maria Frey, A. Carballedo, L. V. Velzen, M. V. Tol, N. Wee, I. Veer, Henrik Walter, K. Schnell, E. Schramm, C. Normann, D. Schoepf, C. Konrad, B. Zurowski, T. Nickson, A. McIntosh, M. Papmeyer, H. Whalley, J. Sussmann, B. Godlewska, P. Cowen, Felix Fischer, Matthias Rose, M. Rose, B. Penninx, P. Thompson, D. Hibar   +67 more
semanticscholar   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Desvenlafaxine in the treatment of major depressive disorder

Neuropsychiatric Disease and Treatment, 2009
Maria Teresa C Lourenco1, Sidney H Kennedy1,21Department of Psychiatry, University Health Network, Toronto; 2Department of Psychiatry, University of Toronto, Toronto, CanadaAbstract: Major depressive disorder (MDD) is among the most incapacitating ...
Maria Teresa C Lourenco1, Sidney H Kennedy1,2   +1 more
doaj  

Suicidal Ideation and Its Associated Factors Among Patients with Major Depressive Disorder at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Neuropsychiatric Disease and Treatment, 2021
Elyas Adamsu Basha,1 Bethelehem Taye Mengistu,1 Nigus Alemnew Engidaw,1 Abate Dargie Wubetu,1 Assalif Beyene Haile2 1Department of Nursing, College of Health Science, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Midwifery, College of ...
Basha EA, Mengistu BT, Engidaw NA, Wubetu AD, Haile AB   +4 more
doaj  

The reliability and validity of PHQ-9 in patients with major depressive disorder in psychiatric hospital

BMC Psychiatry, 2019
Background To assess the reliability and validity of Patient Health Questionnaire-9 (PHQ-9) for patients with major depressive disorder (MDD) and to assess the feasibility of its use in psychiatric hospitals in China. Methods One hundred nine outpatients
Yue Sun, Zhao-yan Fu, Qijing Bo, Zhen Mao, Xin Ma, Chuanyue Wang   +5 more
semanticscholar   +1 more source

Nanoodor Particles Deliver Drugs to Central Nervous System via Olfactory Pathway

Advanced Science, EarlyView.
This study have elucidated the brain‐targeted delivery pathways and transport mechanisms of nanoodors by various technical means and found that the olfactory pathway is main one. Nanoodors can rapidly deliver drugs to the central nervous system via olfactory pathway and will hopefully solve the delivery challenges for various types of central nervous ...
Wei Zhang, Xingwang Ji, Qianyanqiu Zhao, Jinyao Qi, Wen Guo, Gaoshuo Zhang, Yujing Guan, Shenglong Li, Yuling Mao   +8 more
wiley   +1 more source