Results 151 to 160 of about 786,893 (341)

Trial of SAGE-217 in Patients with Major Depressive Disorder.

New England Journal of Medicine, 2019
BACKGROUND Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator of GABA type A receptors, is effective and safe for the treatment of major ...
H. Gunduz-Bruce, C. Silber, I. Kaul, A. Rothschild, R. Riesenberg, A. Sankoh, Haihong Li, R. Lasser, C. Zorumski, D. Rubinow, S. Paul, J. Jonas, J. Doherty, S. Kanes   +13 more
semanticscholar   +1 more source

Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain

Advanced Science, EarlyView.
This study delineates both common and site‐specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways and health status. These findings, particularly those proteins with genetic causal links to pain or predictive capabilities, have the potential to significantly benefit both research and ...
Ze‐Yu Li, Qing Ma, Jie Zhang, Rui‐Ying Yin, Jia You, Qi‐Zheng Hao, Xin‐Rui Wu, Ju‐Jiao Kang, Lin‐Bo Wang, Yue‐Ting Deng, Yu‐Zhu Li, Chun Shen, Bang‐Sheng Wu, Jian‐Feng Feng, Yi‐Heng Tu, Xiao Xiao, Jin‐Tai Yu, Wei Cheng   +17 more
wiley   +1 more source

Cornu Ammonis Changes Are at the Core of Hippocampal Pathology in Depression

Chronic Stress, 2019
Commentary on: Roddy DW, Farrell C, Doolin K, Roman E, Tozzi L, Frodl T, O'Keane V, O'Hanlon E. The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression. Biol Psychiatry. 2019 Mar 15;85(6)
Darren Roddy, Veronica O’Keane
doaj   +1 more source

Sparse whole genome sequencing identifies two loci for major depressive disorder

Nature, 2015
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis.
N. Cai, T. Bigdeli, Warren W. Kretzschmar, Yihan Li, Jieqin Liang, Li Song, Jingchu Hu, Qibin Li, Wei Jin, Zhenfei Hu, Guangbiao Wang, Linmao Wang, Puyi Qian, Yuan Liu, T. Jiang, Yao Lu, Xiuqing Zhang, Ye Yin, Yingrui Li, Xun Xu, Jingfang Gao, M. Reimers, T. Webb, B. Riley, S. Bacanu, Roseann E. Peterson, Yiping Chen, H. Zhong, Zhengrong Liu, Gang Wang, Jing Sun, H. Sang, G. Jiang, Xiaoyan Zhou, Yi Li, Wei Zhang, Xueyi Wang, X. Fang, R. Pan, G. Miao, Qiwen Zhang, Jian Hu, F. Yu, B. Du, W. Sang, K. Li, Guibing Chen, M. Cai, Lijun Yang, Donglin Yang, B. Ha, X. Hong, H. Deng, Gongying Li, Kan Li, Yan Song, Shugui Gao, Jinbei Zhang, Z. Gan, H. Meng, J. Pan, C. Gao, Kerang Zhang, N. Sun, Youhui Li, Q. Niu, Y Zhang, Tieqiao Liu, Chunmei Hu, Zhen Zhang, L. Lv, Jicheng Dong, Xiao-ping Wang, M. Tao, Xumei Wang, Jing Xia, H. Rong, Qiang He, Tie-bang Liu, Guoping Huang, Q. Mei, Zhenming Shen, Y. Liu, Jianhua Shen, T. Tian, Xiaojuan Liu, Wenyuan Wu, D. Gu, G. Fu, Jian-guo Shi, Yunchun Chen, Xiangchao Gan, Lan-fen Liu, Lina Wang, Fuzhong Yang, E. Cong, J. Marchini, Huanming Yang, Jian Wang, S. Shi, R. Mott, Qi Xu, Jun Wang, K. Kendler, J. Flint   +104 more
semanticscholar   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

High level of pattern glare in major depressive disorder

BMC Psychiatry, 2019
Background Visual deficits have been reported in abundance by recent studies on major depressive disorder. Pattern glare manifests as visual distortions, such as the symptoms of headache, glare, eyestrain, illusions of shapes, colors, and motion when ...
Xiongwei Qi, Huanhuan Fan, Xiao Yang, Yayun Chen, Wei Deng, Wanjun Guo, Qiang Wang, Eric Chen, Tao Li, Xiaohong Ma   +9 more
doaj   +1 more source

Machine learning approaches in Detecting the Depression from Resting-state Electroencephalogram (EEG): A Review Study [PDF]

arXiv, 2019
In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major depressive disorder (MDD). We are reviewing and discussing findings based on neuroimaging studies (MRI and fMRI) first to
arxiv  

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

The effects of coloring therapy on patients with generalized anxiety disorder

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 502-512, December 2022., 2022
After the intervention, there were statistical differences intra‐and‐inter group comparisons of anxiety, depression, and positive and negative mood scales in the experimental and control groups (p < .05). The minus in anxiety/positive emotions pre‐and‐post intervention in the experimental group was statistically significant compared to the minus in ...
Bosomtwe Samuel, Hongmei Wang, Chengdong Shi, Yongliang Pan, Yuzi Yu, Weiyu Zhu, Zhou Jing   +6 more
wiley   +1 more source