Results 151 to 160 of about 514,237 (285)

Differential Neural Dynamics in Psychomotor Retardation and Agitation of Depression. [PDF]

Hum Brain Mapp
Liang Q, Xu Z, Chen S, Lin S, Lin X, Li Y, Zhang Y, Peng B, Hou G, Qiu Y, Northoff G.   +10 more
europepmc   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Positive memory enhancement training for individuals with major depressive disorder [PDF]

, 2018
De Raedt, Rudi, Hall, K. A. A., Joormann, Jutta, Timpano, Kiara R   +3 more
core   +2 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Circulating Orexin-A Levels in Patients With Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Almahwzi S, Ghabashi S, Alyami W, Alsolami J, Juma R, Alghamdi S, Althobyane L, Alqahtani M, Alotaibi M.   +8 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Temperament and major depressive disorder

Annals of General Psychiatry, 2010
Mneimneh Zeina, Yeretzian Joumana S, Salamoun Mariana M, Karam Elie G, Karam Aimee N, Fayyad John   +5 more
doaj   +1 more source

Factors associated with violence in bipolar disorder versus major depressive disorder: insights from a retrospective cross-sectional study of 141 aged patients with mood disorders. [PDF]

Front Psychiatry
Ye J, Zhou T, Lei L, Mo L, Chen J, Wang W, Wei Y, Lu X, Yuan L, Wu S, Li Z, Zheng D, Xiao A.   +12 more
europepmc   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Effects of the COVID-19 pandemic on the emotional disorders of adolescents from rural high schools in Dobrogea, Romania. [PDF]

Front Psychiatry
Enache RG, Sălceanu C, Matei RS, Ilie Miloş CA.   +3 more
europepmc   +1 more source