Results 161 to 170 of about 496,245 (299)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Improving the diagnosis of bipolar disorder through machine learning - when is the time right? [PDF]

Neurosci Appl
Klahn AL.
europepmc   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Leptin a potential link between obesity and depression. [PDF]

Cell Mol Life Sci
Hontecilla-Prieto L, García-Domínguez DJ, Berlanga-Gil C, Flores-Campos R, Muñoz-Pacheco R, Franco-Fernández MD, Flores-Cordero JA, Sánchez-Jiménez F, Pérez-Pérez A, Vilariño-García T, Sánchez-Margalet V.   +10 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Association of prior history of suicide attempt and disease severity and subsequent suicidal acts among patients with psychiatric disorders in North China: a multicentre prospective study protocol. [PDF]

BMJ Open
Wu J, Min J, Luo Y, Li P, Li L, Ge Y, Yun Y, Lei C, Wang Q, Zhou F, Yin Y, Tong Y.   +11 more
europepmc   +1 more source

Positive memory enhancement training for individuals with major depressive disorder [PDF]

, 2018
De Raedt, Rudi, Hall, K. A. A., Joormann, Jutta, Timpano, Kiara R   +3 more
core   +2 more sources

Shared cortical characteristics in major depressive disorder, anxiety disorder, and chronic pain: a structural MRI meta-analysis study. [PDF]

Transl Psychiatry
Yu W, Tao B, Zhu F, Gao Z, Xiao Y, Gong Q, Lui S.   +6 more
europepmc   +1 more source

Dual‐Terminal Molecular Strategy for Robust and Reversible Supramolecular Adhesion

Advanced Science, EarlyView.
A minimalist supramolecular adhesive derived from a dual‐terminal molecule bearing carboxylic acid and triphenylphosphonium groups achieves strong, reversible adhesion through synergistic noncovalent interactions. The system exhibits rapid curing, broad substrate compatibility, and exceptional stability under solvents, humidity, and extreme ...
Shiru Wang, Liang Meng, Feng Li, Yuru Wang, Yongri Liang, Guangming Lu, Keju Sun, Yingdan Liu, Jingyue Yang   +8 more
wiley   +1 more source