Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. [PDF]
In a genome-wide association study (GWAS) meta-analysis of 688,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries across diverse and admixed ancestries, we identify 697 associations at 635 loci, 293 of which are novel ...
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium +1 more
core +1 more source
Major depressive disorder, personality disorders and coping strategies are independent risk factors for lower quality of life in non-metastatic breast cancer patients. [PDF]
, 2015 International audienceObjective: To identify risk factors for lower quality of life (QOL) in non-metastatic breast cancer patients.Methods: Our study included 120 patients from the University Hospital Centers of Tours and Poitiers.
Aaronson +36 more
core +4 more sources
The Mistreatment of Major Depressive Disorder [PDF]
The Canadian Journal of Psychiatry, 2014 Objective: To examine the effects of classification on treatment in major depressive disorder (MDD). Method: This is a narrative review. Results: MDD is a highly heterogeneous category, leading to problems in classification and in specificity of treatment. Current models classify all depressions within a single category.
openaire +3 more sources
Characteristics of Cerebral Palsy in the Midwestern US
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim +6 more
wiley +1 more source
Major Depressive Disorder: A General Overview [PDF]
SHS Web of ConferencesMajor Depressive Disorder (MDD) has become a serious mental health problem with a lifetime prevalence of 15% to 20%. MDD is associated with significant morbidity, mortality, disability, and negative influence on patient's daily life This article is an ...
Wang Tianqi
doaj +1 more source
Assessment of depression and anxiety in hematological cancer patients and their relationship with quality of life. [PDF]
, 2011 OBJECTIVES:To determine the relationship between major depressive disorder, anxiety disorders and the quality of life of haematological cancer patients.
Awang, Hamidin +5 more
core
Depressive disorders in caregivers of dementia patients: a systematic review. [PDF]
, 2005 Although depressive symptomatology has been well studied in caregivers of patients with dementia, depressive disorders have been examined much less.
Anderson IM +12 more
core +1 more source
CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body composition, nutritional status, and metabolic biomarkers in PD. Methods CSF cf‐mtDNA levels, defined as the
Yasuaki Mizutani +11 more
wiley +1 more source
Neuroinflammatory Hypothesis in Major Depressive Disorder
Psikiyatride Güncel Yaklaşımlar, 2014 Faced with stress and acute instances, brain cells trigger neuroinflammation and increase inflam-mation response and can cause cell damage, cell death and thereby functional insufficiencies, behavioral disorders and autonomic imbalances.
Gulfizar Sozeri-Varma
doaj +1 more source
Parvalbumin Promoter Methylation Altered in Major Depressive Disorder [PDF]
, 2019 Aims: To determine the extent of DNA methylation of parvalbumin gene (PVALB) promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls.
Dalton, Caroline +5 more
core +1 more source