Results 201 to 210 of about 1,946,485 (301)

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

Advanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou, Jianing Jing, Zhuohan Shi, Lei Sun   +3 more
wiley   +1 more source

<i>MTHFR</i> Gene Variants and Major Depressive Disorder in Mexican-Mestizos. [PDF]

Behav Sci (Basel)
Casillas-Ávila MP, Toledo-Lozano CG, Montes Almanza LÁ, Coral-Vázquez RM, Sixtos IR, Medrano Espinosa O, García S, Rodríguez Hernández C, García Martínez FA, González EOZ, García Castillo G, Díaz BG, Benavides MVD, Rosas-Maldonado SA, Gutiérrez Mendoza C, Flores CP, López-Hernández LB.   +16 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Symptom-Domain Correlates of Self-Reported Anxious Distress in Outpatients With Major Depressive Disorder. [PDF]

Neuropsychopharmacol Rep
Oga S, Sugawara N, Kawamata Y, Asahi T, Ono Y, Suzuki S, Hiramatsu R, Yasui-Furukori N.   +7 more
europepmc   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Evidence-Based Pharmacotherapies for Major Depressive Disorder: A Clinical Update. [PDF]

Psychopharmacol Bull
Marques MG, Singh B.
europepmc   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Academic performance in children of mothers with perinatal depressive disorder. [PDF]

Aust N Z J Psychiatry
Tusa BS, Alati R, Ayano G, Dachew B.
europepmc   +1 more source