Results 261 to 270 of about 308,825 (338)

Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra‐performance liquid chromatography

Animal Models and Experimental Medicine, EarlyView.
The active ingredient of the drug determines the effect of the drug, and the compatibility affects the content of the active ingredient of the drug, which in turn affects the exertion of the efficacy. This study partly clarifies the rationality and compatibility of AM‐PR in the treatment of FC.
Xiaoting Wang, Xiaojun Li, Rui Zhang, Yin Hong, Jiaqi Guan   +4 more
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Computational cognitive mechanisms of visual working memory in major depressive disorder and sex differences. [PDF]

BMC Psychol
Kong Q, Liu Q, Gao F, Wang X, Wang Z, Xiao C, Zhang X, Yu Q, Fan J, Zhu X.   +9 more
europepmc   +1 more source

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

Animal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong, Meiru Jiang, Kun Yuan, Fang Sheng, Xiuyun Xu, Yong Cui, Xijia Sun, Wenfei Tan   +7 more
wiley   +1 more source

Immediate memory is associated with alexithymia in Chinese Han first-episode, drug-naïve major depressive disorder. [PDF]

Front Psychiatry
Tian X, Bai FF, Zhao YP, Gao Y, Wang YT, Liu Y, Zhang CH, Li MJ, Li J.   +8 more
europepmc   +1 more source

Effects of pregnancy on neuron electrophysiology in prefrontal cortex, hippocampus, and basolateral amygdala of mouse brain

Animal Models and Experimental Medicine, EarlyView.
The electrophysiological change in neurons might contribute to the cognitive and emotional changes during pregnancy. Abstract Background Pregnancy affects learning and memory in women. Thus, to investigate the effects of pregnancy, the authors examined the brain electrophysiology of pregnant mice.
Xuefan Bin, Huijuan Luo
wiley   +1 more source

Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder. [PDF]

Front Psychiatry
Xu P, Fan C, Yan M, Liu J, Zhang X.
europepmc   +1 more source

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source