Results 261 to 270 of about 3,916,339 (374)

Generalized Mechanism Model for Ecosystem Hysteresis

Advanced Science, EarlyView.
A simplified model examines ecosystem transitions into alternative states after disturbances by leveraging positive and negative feedbacks. It identifies critical tipping points and quantifies hysteresis. Tests conducted on lakes, grasslands, and pitcher‐plant leaves align closely with empirical data and enable the prediction of recovery trajectories ...
Yanbin Hao, Xin Wang, Jie Liu, Mingzi Wu, Jianqing Du, Kai Xue, Xiaoning Song, Xiaoyong Cui, Tong Zhao, Yanfen Wang   +9 more
wiley   +1 more source

Improvement in avoidance in major depressive disorder: A 10-month prospective study of depressive symptoms and personality traits. [PDF]

PCN Rep
Higuchi R, Nakagawa A, Mitsuda D, Nogami W, Amano M, Ihara S, Ito A, Noda S, Katayama N, Kocha H.   +9 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder. [PDF]

Ann Med Surg (Lond)
Rasheed S, Arif R, Raza AA, Samadi A.
europepmc   +1 more source

Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta‐analysis

World Psychiatry, 2015
D. Vancampfort, B. Stubbs, A. Mitchell, M. De Hert, M. Wampers, P. Ward, S. Rosenbaum, C. Correll   +7 more
semanticscholar   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder.

JAMA Psychiatry
Walker A, Mitchell BL, Lin T, Crouse JJ, Albiñana C, Yap CX, Lynall ME, Lind PA, Cipriani A, Byrne EM, Medland SE, Martin NG, Taquet M, Hickie IB, Wray NR.   +14 more
europepmc   +1 more source

Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis

World Psychiatry, 2016
D. Vancampfort, C. Correll, B. Galling, M. Probst, M. De Hert, P. Ward, S. Rosenbaum, F. Gaughran, J. Lally, B. Stubbs   +9 more
semanticscholar   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample.

American Journal of Psychiatry, 2017
P. Pan, J. Sato, G. Salum, L. Rohde, A. Gadelha, A. Zugman, J. Mari, A. Jackowski, F. Picon, E. Miguel, D. Pine, E. Leibenluft, R. Bressan, A. Stringaris   +13 more
semanticscholar   +1 more source