Results 271 to 280 of about 3,916,339 (374)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Long-Term Use of Benzodiazepines and Related Drugs in Persons With Major Depressive Disorder. [PDF]

Brain Behav
Laitinen H, Tiihonen M, Tanskanen A, Tiihonen J, Lieslehto J, Koponen M, Taipale H.   +6 more
europepmc   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

The Role of Willpower in Major Depressive Disorder: An fMRI Study. [PDF]

Brain Behav
Yulug B, Uygur B, Sayman D, Cankaya S, Ayyıldız B, Ayyıldız S, Oktem EO, Akturk A, Ozsimsek A, Salar AB, Ozansoy M, Hanoglu L, Altay O, Velioglu HA, Mardinoglu A.   +14 more
europepmc   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Novel TMS-derived metrics enable machine learning classification of major depressive disorder. [PDF]

NPP Digit Psychiatry Neurosci
López Pereyra S, R Mazzotti D, Oathes D, Goldschmied JR.   +3 more
europepmc   +1 more source

Depressive Disorders [PDF]

, 1999
openaire   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Utility of therapeutic drug monitoring in the treatment of major depressive disorder. [PDF]

Curr Opin Psychiatry
Schoretsanitis G, Paulzen M.
europepmc   +1 more source

Major depressive disorder and immunity to varicella-zoster virus in the elderly

, 2011
Michael R. Irwin, Myron J. Levin, Carmen Carrillo, Richard G. Olmstead, Anne Lucko, Nancy Lang, Michael J. Caulfield, Adriana Weinberg, Ivan S. F. Chan, J. Benjamin St. Clair, Jeff Smith, Rocio D. Marchese, Heather Williams, Danielle Beck, Patricia T. McCook, Gary R. Johnson, Michael N. Oxman   +16 more
openalex   +2 more sources