Results 321 to 330 of about 3,916,339 (374)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Inflammatory indices are associated with non-suicidal self-injury in adolescents with major depressive disorder. [PDF]

BMC Psychiatry
Zhang W, Zhang Y, Xu T, Wang Y, Yu E, Yue J.   +5 more
europepmc   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Shared neurobiological changes in individuals with Crohn's disease and major depressive disorder. [PDF]

Commun Med (Lond)
Hartmann HA, Berthold ML, Ramkiran S, Bündgens L, Jaeger JW, Hagen J, Backhaus M, Collée M, Schnellbächer GJ, Veselinović T, Shah NJ, Schneider KM, Rajkumar R, Neuner I.   +13 more
europepmc   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Clinical behavior toward outpatients with major depressive disorder based on guideline education for psychiatrists. [PDF]

PCN Rep
Yamagata H, Ide K, Ochi S, Iga JI, Fukumoto K, Ichihashi K, Katsumoto E, Takeshima M, Imai K, Shimamura Y, Matsumoto J, Hasegawa N, Kawamata Y, Tsuboi T, Numata S, Ohi K, Watanabe K, Yamada H, Hori H, Hashimoto R, Yasui-Furukori N.   +20 more
europepmc   +1 more source

Mislabeling Chronic Depression: A Case Report of Persistent Depressive Disorder Misdiagnosed for 12 Years. [PDF]

Cureus
Hegazi T, Jamir J, Hegazi A, Elhassan Y.
europepmc   +1 more source

A holistic Ayurvedic approach to manage persistent depressive disorder, Vishada-A case report. [PDF]

J Ayurveda Integr Med
Khan AZ, Varghese J, Deshmukh C, Khade P, Mirza SK, Mathew M.   +5 more
europepmc   +1 more source