Results 161 to 170 of about 1,014,675 (337)

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Sex-specific roles of cellular inflammation and cardiometabolism in obesity-associated depressive symptomatology. [PDF]

, 2019
BackgroundObesity and depression are complex conditions with stronger comorbid relationships among women than men. Inflammation and cardiometabolic dysfunction are likely mechanistic candidates for increased depression risk, and their prevalence differs ...
Cabrera, Yesenia, Dimitrov, Stoyan, Guay-Ross, Nicholas, Hong, Suzi, Kohn, Jordan N, Pruitt, Christopher, Shaikh, Farah D   +6 more
core   +1 more source

Relationships between depressive symptoms and brain responses during emotional movie viewing emerge in adolescence

, 2019
David C. Gruskin, Monica D. Rosenberg, Avram J. Holmes   +2 more
openalex   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Association of Everyday Discrimination With Depressive Symptoms and Suicidal Ideation During the COVID-19 Pandemic in the All of Us Research Program [PDF]

, 2022
Young A Lee, Zhaowen Liu, Daniel Fatori, Joshua Bauermeister, Rebecca A. Luh, Cheryl R. Clark, Sarah Bauermeister, André R. Brunoni, Jordan W. Smoller   +8 more
openalex   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

IMPLICATIONS OF VIOLENT AND CONTROLLING UNIONS FOR MOTHERS’ MENTAL HEALTH AND LEAVING [PDF]

We used two waves of the Fragile Families Study (N = 2639) to examine links between control and violence with maternal mental health and relationship dissolution.
Claire M. Kamp Dush, Kate S. Adkins
core  

A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy—Adolescent Skills Training To Group Counseling In Schools [PDF]

, 2016
Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a ...
Benas, J. S., Gallop, R., Gillham, Jane, Mufson, L., Schueler, C. M., Young, J. F.   +5 more
core   +1 more source

Why mobile social media-related fear of missing out promotes depressive symptoms? the roles of phubbing and social exclusion [PDF]

, 2023
Bin Gao, Quanwei Shen, Gui Luo, Yiwen Xu
openalex   +1 more source