Results 171 to 180 of about 1,014,675 (337)

Symptoms of agitated depression and/or akathisia.

Psychiatria Danubina, 2011
Akathisia is a syndrome characterized by the unpleasant sensation of "inner" restlessness that manifests itself in the inability of sitting still or not moving. Many types of medicaments can cause akathisia as an adverse event of their use and they include: antipsychotics, antidepressants, antiemetics, antihistamines, and psychoactive substances.
Vučić Peitl, Marija, Prološčić, Joško, Blažević-Zelić, Sandra, Škarpa-Usmian, Ivona, Peitl, Vjekoslav   +4 more
openaire   +4 more sources

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

An exploratory study on internet addiction, somatic symptoms and emotional and behavioral functioning in school-aged adolescents [PDF]

, 2017
Objective: In the last two decades there has been a significant transformation regarding the use of new technologies. Despite growing acknowledgement concerning the different activities and functions of digital technologies, there remains a lack of ...
Cerutti, R., Fontana, A., Guidetti, V., Presaghi, F., Spensieri, V., Valastro, C.   +5 more
core  

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Personalized treatments for depressive symptoms in patients with advanced heart failure: A pragmatic randomized controlled trial

, 2021
Waguih William IsHak, Samuel Korouri, Tarneem Darwish, Brigitte Vanle, Jonathan Dang, Gabriel G. Edwards, Jeanne T. Black, Harriet Aronow, Asher Kimchi, Brennan Spiegel, Rebecca Hedrick, Robert A. Chernoff, Márcio A. Diniz, James Mirocha, Vicki Manoukian, John Harold, Michael Ong, Kenneth B. Wells, Michèle A. Hamilton, Itai Danovitch   +19 more
openalex   +2 more sources

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

Association among obesity, insulin resistance, and depressive symptoms: a mediation analysis

BMC Psychiatry
Background The mechanistic role of insulin resistance(IR) between obesity and Depressive Symptoms has long been debated. Objective This study aims to explore the relationship between BMI and Depressive Symptoms to investigate the mediating role of IR in ...
Guoqiang Xiao, Chenghua Lin, Qiaoyu Lan, Zitong Huang, Chumeng Zhou, Jiajia Hu, Ying Cui, Lujie Wang, Borong Zhou   +8 more
doaj   +1 more source

Bidirectional Longitudinal Study of Frailty and Depressive Symptoms Among Older Chinese Adults [PDF]

, 2022
Limin Cao, Yuhan Zhou, Huiyuan Liu, Mengyuan Shi, Yingliang Wei, Yang Xia   +5 more
openalex   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source