Results 51 to 60 of about 444,031 (314)

Total and Partial Sleep Deprivation in Clomipramine-Treated Endogenous Depressives [PDF]

, 1990
Improvement in depression after total sleep deprivation (TSD) is, as a rule, followed by relapse after subsequent ad libitum sleep. This study is addressed to the question of how nocturnal partial sleep following TSD affects this relapse.
Beersma, Domien,, Elsenga, Simon,, Beersma, Domien, Hoofdakker, Rutger H. van den,, Elsenga, Simon, Hoofdakker, Rutger H. van den   +5 more
core   +1 more source

Observar a pobreza em Portugal: Uma leitura crítica das principais abordagens à operacionalização do conceito de pobreza

Forum Sociológico, 2010
O desenvolvimento de uma medida objectiva, consensual, adequada para a observação da pobreza em Portugal, apoiada em investigação científica, e que permita determinar o rendimento necessário para obter o nível de vida mínimo aceitável no nosso país é um ...
Elvira Sofia Leite de Freitas Pereira
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

COMPASS Guidelines for Conducting Welfare-Focused Research into Behaviour Modification of Animals

Animals
Researchers are increasingly engaged in studies to determine and correct negative welfare consequences of animal husbandry and behaviour modification procedures, not least in response to industries’ growing need to maintain their social licence through ...
Paul D. McGreevy, David J. Mellor, Rafael Freire, Kate Fenner, Katrina Merkies, Amanda Warren-Smith, Mette Uldahl, Melissa Starling, Amy Lykins, Andrew McLean, Orla Doherty, Ella Bradshaw-Wiley, Rimini Quinn, Cristina L. Wilkins, Janne Winther Christensen, Bidda Jones, Lisa Ashton, Barbara Padalino, Claire O’ Brien, Caleigh Copelin, Colleen Brady, Cathrynne Henshall   +21 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Social deprivation and exposure to health promotion. A study of the distribution of health promotion resources to schools in England [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 Chivu and ReidpathBACKGROUND: Area deprivation is a known determinant of health.
Chivu Corina M, Chivu, CM, Corina M Chivu, Reidpath, Daniel, Daniel D Reidpath, Chivu, Corina M, Reidpath Daniel D, Chivu, Corina, Reidpath, DD   +8 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Distributional change, reference groups and the measurement of relative deprivation [PDF]

This paper attempts to explicitly integrate the idea of reference group when measuring relative deprivation. It assumes that in assessing her situation in society an individual compares herself with individuals whose environment can be considered as ...
Jacques Silber, Paolo Verme
core   +2 more sources

Two classes of generalized deprivation indexes [PDF]

The paper uses two particular formulations of the Gini index to derive two different relative deprivation measures. We then generalize the formulation of these measures following Donaldson and Weymark (1980) and Berrebi and Silber (1985) and show how ...
Paolo Verme
core   +2 more sources