Results 81 to 90 of about 444,031 (314)

The sensitive period for the morphological effects of monocular deprivation in two nuclei of the tectofugal pathway of zebra finches

, 1988
Herrmann K, Bischof H-J. The sensitive period for the morphological effects of monocular deprivation in two nuclei of the tectofugal pathway of zebra finches. Brain Research.
Herrmann, Kathrin, Bischof, Hans-Joachim
core   +1 more source

p53 mutation, deprivation and poor prognosis in primary breast cancer [PDF]

, 2010
Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53 mutation might contribute to the impaired outcome observed in patients from deprived ...
P R Quinlan, L Baker, Bourdon, J-C; id_orcid, Baker, L., C A Purdie, Birse-Stewart-Bell, L-J, Dewar, J.A., Dewar, J. A., J A Dewar, A M Thompson, Thompson, A.M., Birse-Stewart-Bell, L.-J., Purdie, C.A., Quinlan, P. R., Quinlan, P.R., Ashfield, A., C McCowan, J-C Bourdon, Jordan, L.B., Thompson, A.M, Wu, L., L-J Birse-Stewart-Bell, A Ashfield, L Wu, Patten, N., N Patten, Mccowan, C., Jordan, L. B., Bourdon, J.-C., Purdie, C. A., L B Jordan   +30 more
core   +1 more source

Deprivation-related and use-dependent plasticity go hand in hand

eLife, 2013
Arm-amputation involves two powerful drivers for brain plasticity—sensory deprivation and altered use. However, research has largely focused on sensory deprivation and maladaptive change. Here we show that adaptive patterns of limb usage after amputation
Tamar R Makin, Alona O Cramer, Jan Scholz, Avital Hahamy, David Henderson Slater, Irene Tracey, Heidi Johansen-Berg   +6 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Dimensions of childhood adversity differentially affect autonomic nervous system coordination in response to stress

Stress
It is well-established that disrupted autonomic nervous system (ANS) reactivity exacerbates risk for long-term maladjustment following childhood adversity (CA).
Meredith A. Gruhn, Rachel E. Siciliano, Allegra S. Anderson, Allison Vreeland, Lauren M. Henry, Kelly H. Watson, George M. Slavich, Jon Ebert, Tarah Kuhn, Bruce E. Compas   +9 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Developmental programming of auditory learning

Journal of Pediatric and Neonatal Individualized Medicine, 2012
The basic structures involved in the development of auditory function and consequently in language acquisition are directed by genetic code, but the expression of individual genes may be altered by exposure to environmental factors, which if favorable ...
Melania Puddu, Vassilios Fanos
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source