Results 61 to 70 of about 1,197,831 (310)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Size and emotion or depth and emotion? Evidence, using Matryoshka (Russian) dolls, of children using physical depth as a proxy for emotional charge

, 2013
Background: The size and emotion effect is the tendency for children to draw people and other objects with a positive emotional charge larger than those with a negative or neutral charge.
Thom Baguley, Taylor, N, Nicola Taylor, Baguley, T, Dunn, AK, Andrew K Dunn   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of air temperature and water depth on bird abundance: A case study of rallidae and anatidae in the northeastern Algerian Garaet Hadj Tahar [PDF]

, 2019
Water birds have traditionally been used as ecological indicators to monitor natural habitats and wetland changes. Climate is widely recognized as a major predictor of bird abundance and richness along large-scale environmental gradients, but mechanisms ...
Segura, Luciano Noel, Bara, Mouslim
core   +1 more source

Effect of tailwater depth on local scour downstream of horizontal jets [PDF]

علوم و مهندسی آبیاری, 2010
In this paper the results of an experimental study on the effect of tailwater depth on the mechanism of scouring downstream of hydraulic jumps is presented.
Mohammad Hosain Omid, Hossein Hamidifar, Mohsen Nasr Abadi   +2 more
doaj   +1 more source

Adjacency and surroundedness in the depth effect on lightness

Journal of Vision, 2010
Using two perpendicular planes, one brightly and one dimly illuminated, A. L. Gilchrist (1977) showed that target lightness can change nearly from black to white by changing its perceived spatial position, with no change in the retinal image, if the target has an adjacent coplanar neighbor in each position. Earlier L. Kardos (1934) found a modest depth
Ana, Radonjić, Dejan, Todorović, Alan, Gilchrist   +2 more
openaire   +2 more sources

On the effective depth of viral sequence data [PDF]

Virus Evolution, 2017
Genome sequence data are of great value in describing evolutionary processes in viral populations. However, in such studies, the extent to which data accurately describes the viral population is a matter of importance. Multiple factors may influence the accuracy of a dataset, including the quantity and nature of the sample collected, and the subsequent
Illingworth, Christopher J.R., Roy, Sunando, Beale, Mathew A., Tutill, Helena, Williams, Rachel, Breuer, Judith   +5 more
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Measuring the strength of brittle materials by depth-of-penetration testing [PDF]

, 2010
Based on an energy conservation model, the strength offered by a number of brittle materials has been calculated from depth-of-penetration (DOP) test results. Each material was completely penetrated by a tungsten carbide cored projectile of known kinetic
Hazell, Paul J., P J Hazell
core   +1 more source

Effect of Cohesive and Non-Cohesive Soils on Equilibrium Scour Depth

Tikrit Journal of Engineering Sciences, 2007
In this research ,the effect of cohesive soils ( clay ) and non –cohesive soils sand on equilibrium scour depth was studied .Experiments were carried out on two types of clay and two types of sand as a bed material using an obstruction ( pier ) to create
Saleh Issa Khassaf
doaj   +1 more source