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Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Employment Protection Deregulation and Labor Shares in Advanced Economies
This paper assesses the impact of job protection deregulation on the labor share in a sample of 26 advanced economies during the 1970–2013 period, using a newly constructed dataset of major reforms in this area.
Gabriele Ciminelli, R. Duval, D. Furceri
semanticscholar +1 more source
Japan's Big Bang and the Transformation of Financial Markets [PDF]
A first step in the 'big bang' markets was the deregulation of the foreign exchange market on April 1, 1998. This paper examines how the bid-ask spread and conditional volatility in the yen/dollar foreign exchange market changed around the time of the ...
Michael Melvin, Takatoshi Ito
core
Inflation targeting and product market deregulation : [Version Januar 2012] [PDF]
I evaluate the effect of inflation targeting on inflation and how it interacts with product market deregulation during the disinflationary process in the 1990s.
Moretti, Laura
core
Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao +7 more
wiley +1 more source
SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Despite decades of study, effective treatments for AD are lacking. Mitochondrial dysfunction has been closely linked to the pathogenesis of AD, but the relationship between ...
Junghee Lee +13 more
semanticscholar +1 more source
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Deregulacja zawodów prawniczych i jej wpływ na konkurencję na rynku usług prawniczych
Competition is an important part of the market, also the legal services market. Legal professions such as advocate, solicitor and notary are liberal professions. The aims of the deregulation have an economic background.
Krystyna Nizioł
doaj +1 more source
Transposable Elements in Human Cancer: Causes and Consequences of Deregulation
Transposable elements (TEs) comprise nearly half of the human genome and play an essential role in the maintenance of genomic stability, chromosomal architecture, and transcriptional regulation. TEs are repetitive sequences consisting of RNA transposons,
S. Anwar, W. Wulaningsih, U. Lehmann
semanticscholar +1 more source
A time series analysis of wages in deregulated industries: A study of motor carriage and rail [PDF]
Using time series techniques, we contrast the impact of deregulation in trucking and rail labor markets. During regulation both labor markets were characterized by wages considerab y higher than manufacturing wages. In fact, trucking and rail wages had a
John Bitzan +2 more
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