Results 101 to 110 of about 437,480 (390)

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, EarlyView.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +2 more sources

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

Nature Communications, 2016
F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and activated mitochondrial permeability transition (mPT), defects which accompany Alzheimer’s
Simon J. Beck, Lan Guo, Aarron J. Phensy, Jing Tian, Lu Wang, Neha Tandon, E. Gauba, Lin Lu, J. Pascual, S. Kroener, Heng Du   +10 more
semanticscholar   +1 more source

Deregulation of Business [PDF]

What determines the enforcement of deregulation reform of business activities? What are the outcomes of deregulation? We address these questions using an episode of a drastic reform in Russia between 2001 and 2004 which liberalized registration ...
Ekaterina Zhuravskaya, Evgeny Yakovlev
core  

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

An historical overview of problems associated with the formalization of the South African minibus taxi industry

Contree, 2009
Die minibus taxi bedryf in Suid-Afrika is ’n belangrike afdeling van die vervoerstelsel, en daarom is dit ’n beduidende faktor in die nasionale ekonomie.
Mark Ingle
doaj   +1 more source

The Employment Effects of Labor and Product Markets Deregulation and their Implications for Structural Reform [PDF]

This study explores the effects of labor and product market deregulation on employment growth. Our empirical results, based on an OECD country panel from 1990-2004, suggest that lower levels of product and labor market regulation foster employment growth,
Helge Berger, Stephan Danninger
core  

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Régulation et institutions en économie du sport

Revue de la Régulation, 2007
Regulation and institutional choice in sports economics. Different institutional options are compared between North American (closed league) and European  (open league) professional sports.
Wladimir Andreff
doaj   +1 more source

Deregulation of Rho GTPases in cancer

Small GTPases, 2016
In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers.
A. Porter, A. Papaioannou, A. Malliri
semanticscholar   +1 more source