Results 111 to 120 of about 381,604 (329)

An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca2+ dynamics

open access: gold, 2021
Haruki Odaka   +12 more
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk   +4 more
wiley   +1 more source

Generating the Benefits of Competition: Challenges and Opportunities in Opening Electricity Markets [PDF]

open access: yes
The move from regulation to competition in different parts of the economy is one of the great success stories of the past 30 years. And more competition in the electricity sector could offer lower consumer prices and improved stability of supply.
Tim Brennan
core  

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li   +7 more
wiley   +1 more source

Input Usage, Ouput Mix and Industry Deregulation: An Analysis of the Australian Dairy Manufacturing Industry [PDF]

open access: yes
In this paper we estimate a Translog output distance function for a balanced panel of state level data for the Australian dairy processing sector. We estimate a fixed effects specification employing Bayesian methods, with and without the imposition of ...
Hristos Doucouliagos   +2 more
core  

Policy Spandrels: How Design Decisions Can Open Up Spaces for Unintended Policy Change

open access: yesEuropean Policy Analysis, EarlyView.
ABSTRACT This article introduces the concept of policy spandrels to make sense of public policies producing second‐order effects that are unintentional from the perspective of policy design and yet are fraught with consequences. By analogy with architectural spandrels—leftover spaces that can be used for unforeseen purposes—policy change can be enabled
Martino Maggetti
wiley   +1 more source

Seamless Electricity Trade between Canada and US Northeast [PDF]

open access: yes
We analyse how the wholesale electricity market deregulation could modify exchanges between three Canadian regions (Ontario, Quebec and New Brunswick) and two U.S.
Bernard, Jean-Thomas   +2 more
core  

Deregulating Naloxone to Combat Opioid-Related Overdoses in British Columbia

open access: yesHealth Reform Observer - Observatoire des Réformes de Santé, 2019
British Columbia fully unscheduled the opioid overdose-reversing drug known as naloxone on 21 September 2016 in an attempt to reduce opioid overdose-related mortality. Having a large population of injectable drug users, the move represents just one harm
Kody Crowell
doaj  

Product Market Deregulation and the U.S. Employment Miracle [PDF]

open access: yes
We consider the dynamic relationship between product market entry regulation and equilibrium unemployment. The main theoretical contribution is combining a job matching model with monopolistic competition in the goods market and individual bargaining. We
Christian Haefke, Monique Ebell
core  

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