Results 191 to 200 of about 6,462,700 (311)

Comparison of the revised Shock Index multiplied by the Glasgow Coma Scale and the Trauma and Injury Severity Score for predicting survival in paediatric patients with trauma: a nationwide retrospective cohort study in Japan. [PDF]

BMJ Open
Minami S, Toida C.
europepmc   +1 more source

The bronchiectasis severity index. An international derivation and validation study.

American Journal of Respiratory and Critical Care Medicine, 2014
J. Chalmers, P. Goeminne, S. Aliberti, M. McDonnell, S. Lonni, J. Davidson, L. Poppelwell, W. Salih, A. Pesci, L. Dupont, T. Fardon, A. De Soyza, A. Hill   +12 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Development and Internal Validation of a Prediction Model for Major Cardiovascular and Respiratory Events in Chronic Obstructive Pulmonary Disease: Nationwide Primary Care Electronic Medical Records Cohort Study. [PDF]

Pragmat Obs Res
Gale CP, Bhutani M, Chan JSK, Townend J, Patel MS, Sadatsafavi M, Henley W, Ariti C, Carter V, Couper A, Hubbard R, Kocks JWH, Pullen R, Skinner D, Price D.   +14 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Automated DWI-FLAIR mismatch assessment in stroke using DWI only. [PDF]

Eur Stroke J
Benzakoun J, Scheldeman L, Wouters A, Cheng B, Ebinger M, Endres M, Fiebach JB, Fiehler J, Galinovic I, Muir KW, Nighoghossian N, Pedraza S, Puig J, Simonsen CZ, Thijs V, Thomalla G, Micard E, Chen B, Lapergue B, Boulouis G, Le Berre A, Baron JC, Turc G, Ben Hassen W, Naggara O, Oppenheim C, Lemmens R.   +26 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Which patients with palliative malignant biliary obstruction will benefit most from biliary drainage: Development and validation of a prognostic score. [PDF]

Endosc Int Open
Olivier R, Antoine E, Morvan M, D'Aubigny A, Nousbaum JB, Reboux N, Perez Cuadrado Robles E, Queneherve L.   +7 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Pattern Formation in Agent-Based and PDE Models for Evolutionary Games with Payoff-Driven Motion. [PDF]

Bull Math Biol
Yao T, Xu C, Cooney DB.
europepmc   +1 more source