Results 201 to 210 of about 5,312,572 (347)

Prediction of adverse events after acute myocardial infarction: derivation and external validation of an extended CHA₂DS₂-VASc score model. [PDF]

BMJ Open
Carlsson L, Leppert J, Selmeryd J, Christersson C, Hedberg P.   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Development and clinical application of an intrapartum ultrasound-based predictive model for cesarean section conversion in nulliparous women following unsuccessful vaginal delivery attempts: A single-center retrospective study. [PDF]

Medicine (Baltimore)
Yu Z, Du S, Xu L, Cheng Y, Hu F, Xu Q.
europepmc   +1 more source

Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2

British medical journal, 2008
J. Hippisley-Cox, C. Coupland, Y. Vinogradova, John Robson, Rubin Minhas, Aziz Sheikh, P. Brindle   +6 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Prediction of histopathological grade in gastric cancer using dual energy CT-derived synthetic extracellular volume fraction. [PDF]

Front Oncol
Zhou HF, Chen W, Li JQ, Sun AY, Guo LL.
europepmc   +1 more source

The infinitesimal model: Definition, derivation, and implications.

Theoretical Population Biology, 2017
N. Barton, A. Etheridge, A. Véber
semanticscholar   +1 more source

Did Debris-Covered Glaciers Serve as Pleistocene Refugia for Plants? A New Hypothesis Derived from Observations of Recent Plant Growth on Glacier Surfaces [PDF]

, 2007
Thomas Fickert, Donald A. Friend, Friederike Grüninger, Bruce F. Molnia, Michael Richter   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Predicting prolonged mechanical ventilation after endovascular treatment for acute vertebrobasilar artery occlusion: AIRFLOW score. [PDF]

Front Neurol
Cai Q, Hong M, Xu Y, Zhang S, Huang Z, Xu P, Chen C, Chen J, Ye L, Sun W.   +9 more
europepmc   +1 more source