Results 211 to 220 of about 1,873,361 (260)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Liver stiffness measurement-based risk score for predicting liver decompensation risk: a single-center retrospective Chinese study. [PDF]

Clin Exp Med
Li Y, Qiao Z, Li J, Li Y, Feng Y, Wang X.   +5 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Elevated Lipoprotein(a) Independently Increases Risk for Short-Term Atherosclerotic Cardiovascular Events in Machine Learning Predictive Models. [PDF]

JACC Adv
Ward A, Kron B, Lozama A, Sandhu A, Khandelwal A, Rodriguez F, Dash R, Nallamshetty S.   +7 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Splenic stiffness does not predict esophageal varices in children with portal hypertension. [PDF]

J Pediatr Gastroenterol Nutr
Jezequel M, El Fayoumi M, Aumar M, Tran L, Saingier C, Behal H, Antoine M, Gottrand F.   +7 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Development and validation of a predictive model for continuous renal replacement therapy in patients undergoing venovenous extracorporeal membrane oxygenation. [PDF]

J Thorac Dis
Xie J, Han L, Ouyang Y, Liu S, Liang Z, Xi Y, Chen X, Wang Y, Li J, Liu Y, He Y, Li J, Zhao L, Yang L, Lai W, Shang Y, Liu L, Liu X, Li Y, Xu Y.   +19 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Chest Computed Tomography-Based Radiomics for the Diagnosis and Prognosis of Pulmonary Hypertension. [PDF]

J Am Heart Assoc
Ruan B, Chen M, Zhuang Q, Guan L, Xie W, Wang L, Zhao Q, Yu S, Wang A, Wang J, Yang M, Shen J.   +11 more
europepmc   +1 more source