Results 251 to 260 of about 303,092 (316)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Development and external validation of prediction models for major osteoporotic fracture and hip fracture in people with intellectual disability. [PDF]

Osteoporos Int
Smith M, Roast J, Collins GS, Holt TA, Frighi V.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A Novel Integrated Perioperative Cardiovascular Risk Score (PERFORM-CV) in Non-Cardiac Surgical Patients. [PDF]

J Cardiovasc Dev Dis
Boghean A, Gutu C, Rebegea LF, Firescu D.   +3 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Comparative pharmacokinetic derivations for axicabtagene ciloleucel and brexucabtagene autoleucel in the treatment of B cell malignancies. [PDF]

Mol Ther Adv
Salunkhe SS, Nater J, Schweitzer C, Mao D, Dong J, Venkkataram R, Xue A, Filosto S, Mattie M, Shen RR.   +9 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Derivation and validation of a new prediction score for bacteremia in the emergency department. [PDF]

Sci Rep
Ohno H, Takahashi J, Kato S, Ishii K, Hiramatsu K.   +4 more
europepmc   +1 more source

Erratum: On the derivation and electrochemical properties of calcium molybdate from zeolitic imidazole frameworks for supercapacitors. [PDF]

iScience
Aiman Bin Abu Sofian AD, Binti Azman NA, Dar MA, Majid SR, Rezakazemi M, Aziz S, Abdullah RM, Show PL.   +7 more
europepmc   +1 more source