Results 71 to 80 of about 6,167,674 (361)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Chemically defined conditions for human iPS cell derivation and culture

Nature Methods, 2011
We re-examine the individual components for human embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all protein reagents for liquid media, attachment surfaces and splitting are ...
Guokai Chen, Daniel R. Gulbranson, Zhonggang Hou, Jennifer M. Bolin, Victor Ruotti, Mitchell D. Probasco, K. Smuga-Otto, S. Howden, Nicole R. Diol, Nicholas E. Propson, Ryan J. Wagner, Garrett Lee, Jessica Antosiewicz-Bourget, Joyce M. C. Teng, J. Thomson   +14 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Model-free derivations of the Tsallis factor: constant heat capacity derivation

, 2002
The constant temperature derivation, which is a model-free derivation of the Boltzmann factor, is generalized in order to develop a new simple model-free derivation of a power-law Tsallis factor based on an environment with constant heat capacity.
Abe, Abe, Abe, Adib, Almeida, Almeida, Andrade, Aringazin, Beck, Carpena, Kaniadakis, Leff, Plastino, Potiguar, Prentis, Tatsuaki Wada, Tsallis, Tsallis, Tsallis, Vallejos, Wilk, Yamano, Yamano   +22 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Derivation of Boltzmann Principle

, 2009
We present a derivation of Boltzmann principle $S_{B}=k_{B}\ln \mathcal{W}$ based on classical mechanical models of thermodynamics. The argument is based on the heat theorem and can be traced back to the second half of the nineteenth century with the ...
Berdichevsky V. L., Boltzmann L., Callen H. B., Chandler D., Donald H. Kobe, Gibbs J., Helmholtz H., Huang K., Landau L., Landau L., Michele Campisi, Münster A., Schlüter A., Sinai Ya. G.   +13 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The bronchiectasis severity index. An international derivation and validation study.

American Journal of Respiratory and Critical Care Medicine, 2014
RATIONALE There are no risk stratification tools for morbidity and mortality in bronchiectasis. Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for future research.
J. Chalmers, P. Goeminne, S. Aliberti, M. McDonnell, S. Lonni, J. Davidson, L. Poppelwell, W. Salih, A. Pesci, L. Dupont, T. Fardon, A. De Soyza, A. Hill   +12 more
semanticscholar   +1 more source

Derived Moduli of Complexes and Derived Grassmannians [PDF]

Applied Categorical Structures, 2016
In the first part of this paper we construct a model structure for the category of filtered cochain complexes of modules over some commutative ring $R$ and explain how the classical Rees construction relates this to the usual projective model structure over cochain complexes.
openaire   +4 more sources