Results 251 to 260 of about 117,485 (309)

Machine learning-based prediction of a high-risk kidney function trajectory class after acute kidney injury. [PDF]

BMJ Health Care Inform
Liu CL, Tain YL, Lin CC, Peng YL, Hsu CN.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Development and external validation of a malnutrition risk prediction model for elderly patients with stable chronic obstructive pulmonary disease using automated machine learning. [PDF]

Medicine (Baltimore)
Guo H, Zhou T, Li S, Yu Y, Han X, Liu X, Shi X, Zhou Y, Zhao R, Zhu J, Shang L.   +10 more
europepmc   +1 more source

On the General Derivatives of the Set Functions

Hiroshima Mathematical Journal, 1930
openaire   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Dual-chirality flexagon linkages with infinite eversion and surface reconfigurability. [PDF]

Proc Natl Acad Sci U S A
Lin J, Miao Z, Zhang H, Dong K, Lu H, Feng H, Dai JS.   +6 more
europepmc   +1 more source

Application of machine learning algorithms to predict and assess factors related to internal carotid siphon aneurysm occlusion treated with flow diversion. [PDF]

Neuroradiology
Li H, Shui S, Ma J, Li T, Guo D.
europepmc   +1 more source

Interpretable machine learning for predicting major amputation risk in hospitalized diabetic foot ulcer patients: a single-center study with temporal external validation. [PDF]

Front Endocrinol (Lausanne)
Zou M, Ju S.
europepmc   +1 more source