Results 211 to 220 of about 1,009,527 (289)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

1,4-Benzo[<i>b</i>]dithiine Derivatives Accessed via Ring Expansion of 1,3-Dithioles. [PDF]

Molecules
Leja DT, Depa WJ, Morawiak M, Bajek-Bil A, Lechowicz JB, Groszek G.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways. [PDF]

PLoS One
Sahin SK, Ali N.
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Correction: Remdesivir-bisPropionate, a better derivative of remdesivir against SARS-CoV-2: Comparison of in vitro and in vivo PK/PD Study as well as its therapeutic potential. [PDF]

PLoS One
Chakraborty A, Diwan A, Chiniga V, Arora V, Thakur Y, Tatake J, Pandey R, Holkar P, Holkar N.   +8 more
europepmc   +1 more source

Validated Near-Infrared Spectroscopy and Chemometric Modelling for Rapid Quantification of Essential Oil Yield and α/β-Santalol in <i>Santalum Album</i> L. [PDF]

Glob Chall
Hassnain M, Azhar MR.
europepmc   +1 more source

An automated derivative-based method for detection of motor evoked potential onset latencies in multi-muscle transcranial magnetic stimulation studies. [PDF]

Sci Rep
Boyles R, Vicente M, Zibordi S, Mallabone J, Strutton PH.   +4 more
europepmc   +1 more source

Synthetic Errors During Solid-Phase Phosphoramidite Synthesis of Oligonucleotides. [PDF]

Molecules
Sherstyuk YV, Dovydenko IS.
europepmc   +1 more source