Results 61 to 70 of about 218,499 (266)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Higher-derivative supersymmetric effective field theories

Journal of High Energy Physics
In this paper we study higher-derivative supersymmetric effective field theories focusing on the systematic procedure for the elimination of ghosts from the spectrum.
Osmin Lacombe, Lorenzo Paoloni, Francisco G. Pedro   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular action of NZ2114, a superior plectasin derivative

npj Antimicrobials and Resistance
NZ2114 is a triple-mutant of the natural peptide antibiotic plectasin that targets the peptidoglycan precursor molecule Lipid II using a supramolecular action, involving assembly of plectasin-Lipid II complexes in a large oligomeric structure, that is ...
Maik G. N. Derks, Shehrazade Jekhmane, Sourav Maity, Vicky Charitou, Cornelis J. Slingerland, Benjamin Vermeer, Mick van der Weijde, Charalampos Ntallis, Nathaniel I. Martin, Wouter H. Roos, Eefjan Breukink, Markus Weingarth   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Ghost-free vector superfield actions in supersymmetric higher-derivative theories

Journal of High Energy Physics, 2017
We systematically construct ghost-free higher-derivative actions of Abelian vector supermultiplets in four-dimensional N = 1 $$ \mathcal{N}=1 $$ global supersymmetric theories.
Toshiaki Fujimori, Muneto Nitta, Keisuke Ohashi, Yusuke Yamada, Ryo Yokokura   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

On the gauge invariance of the higher-derivative Yang–Mills–Chern–Simons action

European Physical Journal C: Particles and Fields
In this work, we study the perturbative generation of the gauge invariant effective action for the non-Abelian gauge field in a $$(2+1)$$ ( 2 + 1 ) -dimensional spacetime. We present a detailed analysis of the two, three and four-point functions in order
M. Ghasemkhani, G. Soleimani, R. Bufalo
doaj   +1 more source

An effective theory of anomalous charge diffusion from holography

Nuclear Physics B
We consider a probe U(1) Maxwell-Chern-Simons theory in 5-dimensions, and analyze the vector perturbations around a classical charged black-brane background. We solve the equations of motion for these perturbations in a derivative expansion. By computing
Jewel K. Ghosh, M. Arshad Momen
doaj   +1 more source