Results 21 to 30 of about 1,209 (145)

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Fluoroquinolones as enhancers of photocarcinogenesis: Proposed pathomechanisms

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022
Fluoroquinolones are photosensitizing drugs in humans, as they can enhance effects of ultraviolet A (UVA) radiation on the skin. UVA causes lesions both to deoxyribonucleic acid and other cellular organelles by Type I and Type II reactions (major and ...
Ricardo Toipa Lopes, Margarida Gonçalo
doaj  

Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations

Allergy, EarlyView.
ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow   +14 more
wiley   +1 more source

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 1042-1050, November 2026.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

Commercial Oat‐Based Cosmetic Ingredients Promote Antioxidant Capacity and Reduce Inflammatory Markers in Skin Cellular Stress Models: An Insight Into Molecular Mechanisms In Vitro

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Dermal products containing oat (Avena sativa L.) have a wide range of benefits on human skin and are commonly incorporated into skincare products. Aims The study focused on evaluating the antioxidant, cytoprotective, and anti‐inflammatory potential of three commercial sources of oat bioactive compounds—Aurafirm P, AvenaPLex, and Oat
Jiří Hanyk, Alena Rajnochová Svobodová, Zdeněk Dostál, Bohumil Zálešák, Jitka Vostálová   +4 more
wiley   +1 more source

A Case of Phototoxic Dermatitis due to Afloqualone

Annals of Dermatology, 1999
Afloqualone, Phototoxic dermatitis. Afloqualone is a centrally acting muscle relaxant and has been used in therapy for musculotensive diseases. A 35-year-old female had been taking afloqulaone for a left hemifacial spasm for one month.The patient visited our hospital with erythematous papules and patches on the sun exposed area.
Ji-Yong Park, Mu-Hyoung Lee
openaire   +1 more source

Allergic contact dermatitis after laser-assisted photodynamic therapy with 5-aminolevulinic acid: evidence of cross-sensitization to methyl aminolevulinate

Photodiagnosis and Photodynamic Therapy
Photodynamic therapy (PDT) is an established treatment for actinic keratosis, with adverse effects usually limited to transient phototoxic reactions. Allergic contact dermatitis (ACD) to topical photosensitizers is rare and has mainly been reported in ...
Svenja Rupp, Martin Vitus, Bernadette Eberlein   +2 more
doaj   +1 more source

The Secretome Derived From Human Umbilical Cord Mesenchymal Stem Cells Improves Skin Photoaging by Enhancing Mitophagy to Inhibit the cGAS‐STING Pathway

Aging Cell, Volume 25, Issue 9, September 2026.
HUC‐MSC‐derived SCT alleviates UV‐induced skin photoaging. It acts by enhancing mitophagy to clear damaged mitochondria, thereby suppressing the pro‐inflammatory cGAS‐STING pathway. This work identifies SCT as a novel cell‐free therapy targeting mitochondrial quality control to counteract sterile inflammation in aging. ABSTRACT Ultraviolet (UV)‐induced
Tingting Tang, Meifen Lin, Jingjing Yang, Xinyu Yang, Xunhong Xu, Xuan Wang, Yarui Zhang, Qimei Chen, Shan Zhao, Chenhui Guo, Hao Zhang, Min Zhang, Lin Zhang, Xueer Wang   +13 more
wiley   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source