Results 51 to 60 of about 360,596 (308)

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Oxyresveratrol Attenuates Inflammation in Human Keratinocyte via Regulating NF-kB Signaling and Ameliorates Eczematous Lesion in DNCB-Induced Dermatitis Mice

Pharmaceutics, 2023
Oxyresveratrol (ORV) is one of the novel antioxidants having been extensively studied in recent years. One of the main sources of ORV is Artocarpus lakoocha, which has been used in traditional medicine in Thailand for decades. However, the role of ORV in
Hung Gia Tran, Aussavashai Shuayprom, Patipark Kueanjinda, Asada Leelahavanichkul, Prapai Wongsinkongman, Siriwan Chaisomboonpan, Apiwat Tawatsin, Kriangsak Ruchusatsawat, Jongkonnee Wongpiyabovorn   +8 more
doaj   +1 more source

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]

, 2004
Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J, Boner AL, Bridgman A, Callen J, Delescluse J, Dooms-Goossens AE, Dykes PJ, Falcoz C, Fisher DA, Goossens A, Harding SM, Hogger P, James M, Johnson M, Johnson M, Juhlin L, Katz HI, Korting HC, Lebwohl M, Li JT, Liu XQ, Llewellyn-Jones CG, Lucky AW, McKenzie AW, McLean HM, Nurnberger FG, Phillipps GH, Roberts DT, Spencer CM, Tharp MD, Venning VA, Wilkinson SM, Wolkerstorfer A, Young MMR   +33 more
core   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Phytochemical Investigation of Equisetum arvense and Evaluation of Their Anti-Inflammatory Potential in TNFα/INFγ-Stimulated Keratinocytes

Pharmaceuticals, 2023
Equisetum arvense L. (Equisetaceae), widely known as ‘horsetail’, is a perennial plant found extensively across Asia. Extracts of E. arvense have been used in traditional medicine, particularly for the treatment of inflammatory disorders.
Se Yun Jeong, Hyung-Seok Yu, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Jin-Chul Kim, Ki Hyun Kim   +6 more
doaj   +1 more source

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Nursing of a case of drug-induced hypersensitivity syndrome complicated with multiple organ failure undergoing continuous renal replacement therapy (1例药物超敏反应综合征合并多脏器衰竭行连续性肾脏替代治疗的护理)

中西医结合护理
This article summarized clinical data and nursing management of a patient with drug-induced hypersensitivity syndrome characterized by toxic epidermal necrolysis and dermatitis combined with multiple organ failure treated with continuous renal ...
SONG Xiaoxiu (宋晓秀), XIAO Li (肖莉)   +1 more
doaj   +1 more source

Effect of Immunotherapy on Basophil Activation Induced by Allergens in Patients with Atopic Dermatitis

Revista Alergia México, 2014
Background: Subcutaneous allergen-specific immunotherapy (IT) is a proved, highly effective treatment for respiratory IgE-mediated diseases. However, few studies have explored the immunological mechanisms of IT in patients with atopic dermatitis ...
Jorge Sánchez, Ricardo Cardona
doaj   +1 more source

Outbreak of tropical rat mite (Ornithonyssus bacoti) dermatitis in a home for disabled persons [PDF]

, 2007
Five mentally handicapped individuals living in a home for disabled persons in Southern Germany were seen in our outpatient department with pruritic, red papules predominantly located in groups on the upper extremities, neck, upper trunk and face.
Beck W, Beck W, Beck W, Betke P, Bichler AJ, Charlesworth EN, Cleland JB, Creel NB, Engel PM, Fishman HC, Fox JG, H. Hofmann, Hetherington GW, J. Baumstark, Tarnick M, Tika-Ram SM, W. Beck   +16 more
core   +1 more source