Results 131 to 140 of about 1,588,155 (297)

Treatment Patterns and Survival Outcomes of Head and Neck Merkel Cell Carcinoma: An Age‐Stratified Analysis

Head &Neck, EarlyView.
ABSTRACT Background H&N Merkel cell carcinoma (MCC) mainly affects elderly patients, yet age‐stratified treatment patterns and outcomes data are scarce. Methods We analyzed 88 consecutive H&N MCC patients (2000–2022) by age (< 75 vs. ≥ 75 years). OS was estimated by Kaplan–Meier analysis and MCC‐specific death with competing‐risks methods (cause ...
Igor Vainer, Lior Strinkovsky, Eyal Fenig, Gideon Bachar   +3 more
wiley   +1 more source

Stereotactic Body Radiation Therapy for Head and Neck Cancers With Perineural Spread

Head &Neck, EarlyView.
ABSTRACT Background Perineural spread (PNS) in head and neck cancer (HNC) is technically challenging due to complex target volumes adjacent to critical organs. Data on stereotactic body radiation therapy (SBRT) for PNS is scarce. Methods This retrospective study included patients treated with SBRT for PNS across two centers in the USA and Canada from ...
Anna K. Lawless, Christopher D. Goodman, Catherine H. Wang, Xin W. Wang, Steven J. Frank, Clifton D. Fuller, Adam S. Garden, G. Brandon Gunn, Amy C. Moreno, William H. Morrison, Jay P. Reddy, David I. Rosenthal, Michael T. Spiotto, Neil D. Gross, Ehab Y. Hanna, Shirley Y. Su, Michael R. Migden, Neal S. Akhave, Renata Ferrarotto, Moran Amit, Anna Lee, Jack Phan   +21 more
wiley   +1 more source

Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders

Biomolecules
Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete.
Ludovica Franceschin, Alessia Guidotti, Roberto Mazzetto, Jacopo Tartaglia, Christian Ciolfi, Mauro Alaibac, Alvise Sernicola   +6 more
doaj   +1 more source

Immunotherapy for Head and Neck Cutaneous Squamous Cell Carcinoma with Perineural Spread: A Systematic Review

Head &Neck, EarlyView.
ABSTRACT Background Immunotherapy is increasingly used for head and neck cutaneous squamous cell carcinoma (cSCC) with perineural spread (PNS), though outcomes remain poorly defined. Methods A systematic review was conducted according to PRISMA and MOOSE guidelines.
Jai Paris, James Tsimiklis, Ayushi Agarwal, Jessica Y. Tong, Dinesh Selva   +4 more
wiley   +1 more source

JAK Inhibitor Safety in Atopic Dermatitis and Alopecia Areata: A 4.5-Year Real-World Retrospective Cohort Study

Dermatology and Therapy
Introduction JAK inhibitors (JAKi) represent a novel therapeutic approach for treating the immune-mediated dermatologic diseases alopecia areata (AA) and atopic dermatitis (AD).
Paola Facheris, Luigi Gargiulo, Luciano Ibba, Mario Valenti, Francesco D’Oria, Giulio Foggi, Costanza Falcidia, Sara Di Giulio, Carlo A. Vignoli, Antonio Costanzo, Alessandra Narcisi   +10 more
doaj   +1 more source

Diabetes Increases Immunotherapy‐Related Toxicity but Not Efficacy in Metastatic Non‐Small Cell Lung Cancer: A Multicenter Retrospective Study

International Journal of Cancer, EarlyView.
ABSTRACT This multicenter retrospective study evaluated the impact of type 2 diabetes mellitus (DM) on clinical outcomes and immune‐related adverse events (irAEs) in 450 patients with metastatic non‐small cell lung cancer (NSCLC) treated with second‐line nivolumab at 17 centers between 2016 and 2024. Among these patients, 118 (26.2%) had DM.
Emre Çakır, Didem Divriklioğlu, Deniz Can Güven, Gamze Serin Özel, Oğuzhan Yıldız, Gamze Emin, Merve Keskinkılıç, Yeşim Ağyol, Onur Yazdan Balçık, Nagihan Kolkıran, Hale Gülçin Yıldırım Doğan, Pervin Can Şancı, Özge Yalıcı, Teoman Şakalar, Yurdagül Danacı, Yakup Düzköprü, Canan Yıldız, Mesut Yılmaz, İlhan Hacıbekiroğlu, Bülent Erdoğan, Saadettin Kılıçkap, Gamze Gököz Doğu, Melek Karakurt Eryılmaz, Atila Yıldırım, İlhan Öztop, İbrahim Vedat Bayoğlu, Şahnura Uzuntaş, Atike Pınar Erdoğan, Emir Çelik, Devrim Çabuk, Erdoğan Selçuk Şeber, Zehra Sadak Öcal, Hacer Demir   +32 more
wiley   +1 more source

Psoriasis in the Era of Targeted Cancer Therapeutics: A Systematic Review on De Novo and Pre-existing Psoriasis in Oncologic Patients Treated with Emerging Anti-neoplastic Agents

Dermatology and Therapy
New advancements in medicine have paved the way for targeted therapies and immune checkpoint inhibitors (ICIs), which have become mainstays of cancer therapy.
Vrinda Madan, Laura I. Ortiz-López, Goranit Sakunchotpanit, Ryan Chen, Krithika Nayudu, Vinod E. Nambudiri   +5 more
doaj   +1 more source

Tumour Antigen‐Specific Antibody Signatures as Diagnostic Biomarkers for Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Early detection of melanoma remains challenging, and minimally invasive diagnostic tools are needed to complement imaging and histopathology. Circulating tumour antigen‐specific antibodies (Abs) are promising biomarkers, but their diagnostic value across melanoma stages is not fully established.
Cristina Vico‐Alonso, Tawany De Carvalho Gil, Maithili Sashindranath, Victoria Mar, Jessica Da Gama Duarte   +4 more
wiley   +1 more source

Biophysical profile by self‐operated clinician‐guided ultrasound versus standard ultrasound: An observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the feasibility and accuracy of remote, clinician‐guided biophysical profile (BPP) assessment using a handheld ultrasound device operated by lay users. Methods This prospective, non‐randomized, quasi‐blinded study compared clinician‐guided ultrasound‐based BPP scans performed remotely by lay users using the Pulsenmore ES ...
Anat Pardo, Shiri Barbash‐Hazan, Anat Shmueli, Michal Eisner, Sharon Sigal, Arnon Wiznitzer, Asnat Walfisch, Tomer Sela, Leor Wolff, Eran Hadar   +9 more
wiley   +1 more source

Assessment and management of dyspareunia in peri‐ and postmenopausal women: A phenotype‐based gynecologic approach

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Dyspareunia in peri‐ and postmenopausal women is common, clinically consequential, and often undertreated in gynecologic practice. Although genitourinary syndrome of menopause (GSM) is a frequent contributor, intercourse‐related pain may also reflect vestibular, pelvic floor, dermatologic, inflammatory, treatment‐related, and psychosocial ...
Marek Broul, Marcel Vančo, Jaroslava Banýrová, Aneta Hujová   +3 more
wiley   +1 more source