Results 101 to 110 of about 11,225 (281)

A retrospective study of the anterolateral thigh perforator flap in the treatment of chronic osteomyelitis of the leg with skin defects

open access: yesJPRAS Open
Background: As a chronic inflammatory process, chronic osteomyelitis is caused by bacterial infections that lead to bone destruction. This disease is more common in patients with open fractures and those undergoing multiple surgical procedures after ...
Zhegang Zhou   +8 more
doaj   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang   +7 more
wiley   +1 more source

Improved Healing of Pressure Ulcers Using Dermapulse, A New Electrical Stimulation Device [PDF]

open access: yes, 1991
A double-blind, clinical study of pulsed electrical stimulation using the Dermapulse® device was carried out on 40 pressure ulcers, randomized to receive either active (stim) or sham treatment.
Gentzkow, Gary D.   +3 more
core   +1 more source

De novo head and neck cancer after liver transplant with antibody-based immunosuppression induction [PDF]

open access: yes, 2018
Background Powerful antibody-based immunosuppression induction is now used routinely during organ transplantation, and may place patients at even higher risk of post-transplant cancer.
Graham, Ryan C.   +2 more
core   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop   +3 more
wiley   +1 more source

A retrospective analysis of the costs and management of genital warts in Italy [PDF]

open access: yes, 2013
BACKGROUND: In Italy the prevalence of genital warts in women (15–64 years) is approximately 0.6% with an incidence of 0.4% per year. Treatments for GW are usually long, with moderate success and high costs.
Carla Maria Zotti   +6 more
core   +1 more source

Advanced therapy medicinal products (ATMPs) – An analysis of the global regulatory status

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Background A rapid progress in the development of advanced therapy medicinal products (ATMPs) has taken place over the past decades. The ATMPs hold great potential but face challenges in the clinical development and the regulatory process.
Allan Cramer   +4 more
wiley   +1 more source

Post-corneal tattooing trigeminal nerve-distributed hyperpigmentation: a case report

open access: yesBMC Ophthalmology
Background keratopigmentation is a proven cosmetic and surgical intervention for corneal irregularities or opaqueness, notably in blind eye. postoperative skin hyperpigmentation localized to a trigeminal nerve distribution has not been documented in any ...
Naif Alsuliman, Shahad Alruwaili
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

open access: yesBMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan   +8 more
wiley   +1 more source

Cutaneous Malignancy Risk in Facial and Hand Vascularized Composite Allotransplantation Recipients: A Review of Immunosuppressive Regimens and Their Oncologic Impact

open access: yesLife
Facial vascularized composite allotransplantation (fVCA) is one of the most complex forms of vascularized composite allotransplantation and requires lifelong immunosuppression to ensure graft survival.
Beatrice Corsini   +3 more
doaj   +1 more source

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