Results 201 to 210 of about 430,220 (382)

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

Neurofibromatosis tipo I y Síndrome de Klippel-Trenaunay

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Se presenta un caso de asociación entre dos enfermedades que afectan la piel y otros órganos: Neurofibromatosis tipo I y Síndrome de Klippel-Trenaunay.
Sahily De la Paz Peña   +2 more
doaj  

A Case Series and Literature Review of Angiosarcoma With Malignant Effusion—A Challenging Cytologic Diagnosis With Dire Prognostic Implications

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course.
Jamie C. Y. Lam   +3 more
wiley   +1 more source

Pleural Metastasis of Merkel Cell Carcinoma

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often challenging to diagnose due to its morphological resemblance to other malignancies. Diagnosis is typically confirmed by immunohistochemistry (IHC), with most cases being positive for both neuroendocrine and epithelial markers, particularly the characteristic
Sina Maghsoudlou   +2 more
wiley   +1 more source

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