Results 111 to 120 of about 59,004 (282)

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients [PDF]

, 2014
Objective: To assess the pharmacodynamic effects of sifalimumab, an investigational anti-IFN-α monoclonal antibody, in the blood and muscle of adult dermatomyositis and polymyositis patients by measuring neutralisation of a type I IFN gene signature ...
Amato, Anthony, Brohawn, Philip, Drappa, Jorn, Fiorentino, David, Greenberg, Steven A, Greth, Warren, Guo, Xiang, Higgs, Brandon W, Jallal, Bahija, Le, Chenxiong, Morehouse, Chris, Rebelatto, Marlon, Richman, Laura, White, Wendy I, Yao, Yihong, Zhu, Wei   +15 more
core   +1 more source

Gingival and Periodontal Diseases and Conditions in Children and Adolescents: Consensus Report

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background The objectives of this Focused Workshop were to update the epidemiology, aetiology, risk factors, diagnosis and management of gingival and periodontal diseases and conditions in children and adolescents, and to explore the applicability of the 2018 Classification in children and adolescents.
Iain Chapple, Sotiria Gizani, Mariano Sanz, Dominique Declerck, Phoebus Madianos, Valerie Clerehugh, Monique Danser, Esti Davidovich, Janet Davies, Nikos Donos, Elisabeth Dursun, Elena Figuero, Filippo Graziani, Mervi Gursoy, Soren Jepsen, Clara Joseph, Moritz Kebschull, Norbert Kraemer, Tina Lambrinaki, Rodrigo López, David J. Manton, Joerg Meyle, Ana Molina, Lior Shapira, Cheryl Somani, Georgios Tsilingaridis, Svante Twetman, Nicola West, Biniyam Wondimu, Ferranti Wong, David Herrera   +30 more
wiley   +1 more source

Dermatomyositis presenting with symptomatic dermographism and raised troponin T: a case report

Journal of Medical Case Reports, 2009
Introduction Dermatomyositis is an important inflammation of skin and muscles. Generalised itch is frequent in the condition; however, symptomatic dermographism has not previously been reported as a presenting feature.
Rahim Kartini F, Dawe Robert S
doaj   +1 more source

Juvenile dermatomyositis [PDF]

, 2011
Juvenile dermatomyositis (JDM) is an important subtype of dermatomyositis characterized by inflammation of muscle, skin and gastrointestinal tract. A 14-year-old girl, with a history of fever, joint pain, easy fatigability and a rash since the age of 3 ...
Ahmed, Shakeel, Ali, Rehan, Ishaque, Sidra, Minhas, Khurram   +3 more
core   +1 more source

Risk factors associated with calcinosis of juvenile dermatomyositis [PDF]

, 2008
OBJETIVO: Identificar fatores de risco associados à calcinose em crianças e adolescentes com dermatomiosite juvenil. MÉTODOS: Prontuários de 54 pacientes com dermatomiosite juvenil foram estudados.
AIKAWA, Nádia E., DORIA-FILHO, Ulysses, LIPHAUS, Bernadete L., MARIE, Suely K. N., PIVATO, Francine C. M. M., SALLUM, Adriana M. E., SILVA, Clovis A. A.   +6 more
core   +3 more sources

Calcinosis Cutis and Delayed‐Onset Myositis in a Case of Suspected Localized Scleroderma: A Diagnostic and Therapeutic Challenge

Pediatric Dermatology, EarlyView.
ABSTRACT A 16‐year‐old girl presenting with calcinosis cutis and localized scleroderma subsequently developed delayed‐onset idiopathic inflammatory myopathy five years after initial skin involvement. Despite the absence of typical dermatomyositis features and negative myositis‐specific antibodies, whole‐body MRI revealed extensive subclinical muscle ...
Edoardo Marrani, Laura Gatti, Ilaria Pagnini, Teresa Oranges, Cesare Filippeschi, Gabriele Simonini   +5 more
wiley   +1 more source

Atypical presentation of anti-small ubiquitin-like modifier 1 and melanoma differentiation-associated gene 5 antibody positive dermatomyositis presenting with significant inflammatory myopathy on biopsy and normal creatine kinase levels: A case report

SAGE Open Medical Case Reports
Idiopathic inflammatory myopathies are characterized by chronic inflammation of skeletal muscle. The main subtypes of idiopathic inflammatory myopathies include dermatomyositis, polymyositis, and necrotizing autoimmune myopathies.
Srikar Sama, Nidaa Rasheed, Kyle Shen, Negar Khanlou, Karam Han, Alicia Rodriguez-Pla   +5 more
doaj   +1 more source

Current pharmacological treatment of idiopathic inflammatory myopathies [PDF]

, 2016
The idiopathic inflammatory myopathies are uncommon and heterogeneous disorders. Their classification is based on distinct clinicopathologic features.
Alves, SC, Fasano, S, Isenberg, DA
core   +1 more source

Galectin‐9 and CXCL10 as Biomarkers for Disease Activity in Juvenile Dermatomyositis: A Longitudinal Cohort Study and Multicohort Validation

Arthritis & Rheumatology, 2019
Objective evaluation of disease activity is challenging in patients with juvenile dermatomyositis (DM) due to a lack of reliable biomarkers, but it is crucial to avoid both under‐ and overtreatment of patients.
J. Wienke, F. Bellutti Enders, Johan Lim, J. Mertens, Luuk L. Hoogen, C. Wijngaarde, Joo Guan Yeo, A. Meyer, Henny G. Otten, R. Fritsch‐Stork, Sylvia S. M. Kamphuis, E. Hoppenreijs, W. Armbrust, J. Berg, P. Hissink Muller, J. Tekstra, J. Hoogendijk, C. Deakin, W. Jager, Joël A. G. Roon, W. L. Pol, K. Nistala, C. Pilkington, M. Visser, T. Arkachaisri, T. Radstake, A. J. Kooi, S. Nierkens, L. Wedderburn, A. Royen-Kerkhof, F. Wijk   +30 more
semanticscholar   +1 more source