Results 191 to 200 of about 124,827 (306)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

EXTENSIÓN UNIVERSITARIA: ¿Invasión Cultural o Desarrollo Personal?

Contexto & Educação, 2013
La extensión universitaria se mantiene en una constante conceptualización y desarrollo. La práctica extencionista universitaria en las escuelas formadoras de maestros há demostrado que hay exigencias que deben cumplirse para el logro más eficiente de sus objetivos en la formación de docentes que se desempeñen como educadores comunitarios y de su ...
openaire   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Aprovechamiento estratégico de la identidad cultural para el empoderamiento económico femenino en el desarrollo territorial

Cooperativismo y Desarrollo
La gestión del desarrollo territorial en Cuba fomenta la transversalización del enfoque de género en interés de incrementar la participación de mujeres y hombres en igualdad de condición y posición como sujetos activos del desarrollo.
Maydelin Annerys Olazabal Arrabal, Vilda Rodríguez Méndez, Ernesto Collado Cardoso, Liz Marian Rio Olazabal   +3 more
doaj  

Knowledge, Attitudes, and Practices in Pediatric Pain Management: Cross-Cultural Adaptation and Initial Psychometric Evaluation of the Polish HUPEDCARE-Q Among Healthcare Students and Professionals. [PDF]

J Clin Med
Szablewska AW, Czerwińska-Osipiak A, Popowicz H, Radzikowski A, Rozmarynowska W, Wójcicka LP, Stefanowicz-Bielska A, Pietrzak K, Krawczyk A, Michalik A, Gaworska-Krzemińska A, Jakimczyk B, García-Valdivieso I, José F.   +13 more
europepmc   +1 more source

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

Social diversity, parenting, and child development promotion: reflections on nursing care. [PDF]

Rev Esc Enferm USP
Bardivia CB, Veríssimo MÓR, Melo EMOP, Mello DF.   +3 more
europepmc   +1 more source

The Illness Narratives of Children and Young People With Spinal Muscular Atrophy: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim(s) This review seeks to explore the illness narratives of children and young people focusing on their healthcare trajectories; the right to health; and the kind of stories told about them. Design This scoping review adopts a narrative approach to analyse how the illness experience of Spinal Muscular Atrophy is represented in the literature,
Marcela González‐Agüero, Constanza Quezada, Valentina Turén, Josefa Camelio, Martina De Filippi, Caroline Bradbury‐Jones, Julie Taylor   +6 more
wiley   +1 more source

A Critical Overview of Mental Health Policies for the Treatment of Schizophrenia in Chile. [PDF]

Actas Esp Psiquiatr
Atencio-Quevedo D, Caqueo-Urízar A, Romero-Romero JC.   +2 more
europepmc   +1 more source

Convergencia histórico-cultural: Centro Desarrollo Agrícola Tolosano

, 2020
El siguiente proyecto final de carrera (P.F.C.) recopila información histórica y contemporánea del barrio de Tolosa localizado en la ciudad de La Plata-BsAs. El trabajo expone los problemas urbano-arquitectónicos que se encuentran en el objeto de estudio: el Predio ferroviario de Tolosa. La instancia propositiva busca mejorar el vínculo entre el predio,
openaire   +1 more source