Results 241 to 250 of about 108,706 (305)

SMAA‐Based FITradeoff: An Efficient Framework for Pairwise Elicitation in Multicriteria Decision Analysis

open access: yesJournal of Multi-Criteria Decision Analysis, Volume 33, Issue 2, August 2026.
ABSTRACT The Flexible and Interactive Tradeoff Elicitation (FITradeoff) method is a Multi‐Attribute Decision‐Making (MADM) approach designed to capture the preferences of a Decision Maker (DM) while minimising cognitive effort. To reduce the frequency of interactions and optimise the preference elicitation process, this paper introduces an innovative ...
Qian Zhao   +3 more
wiley   +1 more source

Nutritional characterization of Cusco green tea and its synergistic effect with omega‐3 on metabolic and cognitive dysfunctions in obese rats

open access: yesJournal of the Science of Food and Agriculture, Volume 106, Issue 9, Page 5643-5657, July 2026.
Abstract BACKGROUND Obesity and its metabolic complications, such as insulin resistance and cognitive decline, remain a global health challenge. Green tea (Camelia sinensis) and ω‐3 polyunsaturated fatty acids (PUFAs) are recognized for their antioxidant, anti‐inflammatory, and neuroprotective properties.
Paola Finetti‐Casanova   +5 more
wiley   +1 more source

Comparative analysis of anti-MICA scFv affinities: Insights from three label-free biophysical methods and biological validation. [PDF]

open access: yesBiotechnol Rep (Amst)
Toledo-Stuardo K   +22 more
europepmc   +1 more source

Phenylalanine Versus Tyrosine (Pos. 367/332 in MCT1/MCT4) in the Substrate Binding Site Defines Affinity and Preferred Directionality of Human Monocarboxylate Transporters 1–4

open access: yesActa Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim Human monocarboxylate transporters 1–4, MCT, are key for the lactate/H+ exchange between glycolytic and oxidative cancer cells, white and red muscle fibers, or in the astrocyte‐neuron shuttle. The common MCT transport mechanism involves three conserved residues, that is, a substrate‐attracting Lys and a conformation‐locking Asp/Arg salt ...
Maike Menzel   +6 more
wiley   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

Early fault detection in gearboxes via dynamic principal component analysis-driven multivariate statistical process control. [PDF]

open access: yesPLoS One
Pérez-Torres A   +4 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

open access: yesBrain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña   +20 more
wiley   +1 more source

Guava Byproducts (<i>Psidium guajava</i> L.) as a Source of Phenolic Compounds with In Vitro Antihyperlipidemic Potential. [PDF]

open access: yesMolecules
Baeza-Jiménez R   +4 more
europepmc   +1 more source

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