Results 41 to 50 of about 1,565 (133)

Fuchs Dystrophy and Cataract: Diagnosis, Evaluation and Treatment

Ophthalmology and Therapy, 2023
Corneal endothelium plays an important role in maintaining hydration homeostasis and clarity of the cornea. Fuchs endothelial corneal dystrophy (FECD) affects the corneal endothelium resulting in edema and characteristic excrescences on the Descemet’s ...
Muhammad Ali, Kyongjin Cho, Divya Srikumaran   +2 more
doaj   +1 more source

Tissue‐level heterogeneity in FECD: Descemet's membrane phenotypes and association with TCF4 CTG18.1 expansion†

The Journal of Pathology, Volume 269, Issue 3, Page 262-264, July 2026.
Abstract Late‐onset Fuchs endothelial corneal dystrophy (FECD) is commonly framed as a corneal endothelial disease characterised by guttae accumulation and progressive thickening of Descemet's membrane (DM). However, clinical forms and evolutionary profiles vary widely.
Sayo Maeno, Yoshinori Oie, Chifune Kai, Kohji Nishida   +3 more
wiley   +1 more source

Delayed Candida keratitis associated with Descemet's stripping endothelial keratoplasty

American Journal of Ophthalmology Case Reports
Purpose: Our purpose is to report a unique case of Candida interface keratitis that remained quiescent for 3 years after Descemet's stripping endothelial keratoplasty (DSEK), within the endokeratoplasty graft itself, in a patient with underlying uveitis ...
Deena Shaath, George Harocopos, James Walsh, Adam Snowden, Augustine Hong, Praneetha Thulasi   +5 more
doaj   +1 more source

Late onset Descemet's membrane detachment: 15 years after limbal lensectomy with vitrectomy for ROP

Indian Journal of Ophthalmology, 2019
A case of stage 4B retinopathy of prematurity (ROP) after successful retinal reattachment surgery with maintained vision presented with hazy cornea with spontaneous Descemet's membrane detachment (DMD) 15 years after the surgery, requiring Descemet ...
Ekta Rishi, Bhaskar Srinivasan, Niharika Singh, Lingam Gopal   +3 more
doaj   +1 more source

Pathological classification of Fuchs endothelial corneal dystrophy into several types and their relationships with CTG18.1 expansion repeats

The Journal of Pathology, Volume 269, Issue 2, Page 182-196, June 2026.
Abstract Late‐onset Fuchs endothelial corneal dystrophy (FECD) is the most common primary disease of the corneal endothelium and the leading indication for corneal transplantation in Western countries. It is characterized by progressive accumulation, over two to three decades, of extracellular matrix (ECM) components in Descemet's membrane (DM ...
Hanielle Vaitinadapoulé, Daria Onitiu, Corantin Maurin, Gauthier Travers, Emmanuel Crouzet, Oliver Dorado‐Cortez, Sylvain Poinard, Zhiguo He, Fabien Forest, Edouard Ollier, Renaud Touraine, Philippe Gain, Jean‐Marc Perone, Gilles Thuret, the French Fuchs Study Group (FFSG), Diane Bernheim, Christophe Chiquet, Vincent Borderie, Tristan Bourcier, Jean‐Louis Bourges, Frédéric Chiambaretta, Béatrice Cochener, Louis Arnould, Florian Baudin, Catherine Creuzot, Vincent Daien, Alexandre Denoyer, Bernard Duchesne, Nicolas Duquesne, Pierre Fournie, Anne‐Sophie Gauthier, Philippe Gain, Gilles Thuret, Louis Hoffart, François Majo, Marc Muraine, Romain Mouchel, Jean Marc Perone, Jean Claude Quintyn, Alexandra Rabot, Alain Saad, Damien Gatinel, Pierre‐Yves Santiago, Jean‐Michel Bosc, David Touboul, Bertrand Vabres   +45 more
wiley   +1 more source

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, Volume 104, Issue 3, Page 333-341, May 2026.
Abstract Purpose To determine the histological differences between Fuchs endothelial corneal dystrophy (FECD) cases with and without the most common genetic risk factor, expansion of a CTG repeat (CTG18.1) within the TCF4 gene. Methods Formalin‐fixed paraffin‐embedded corneal tissues were compared retrospectively, and CTG18.1 status was determined from
Anne‐Marie S. Kladny, Nihar Bhattacharyya, Marcos Abreu Costa, Stephen J. Tuft, Caroline Thaung, Alice E. Davidson   +5 more
wiley   +1 more source

Management of Descemet’s Membrane Detachment after Cataract Surgery—A Case Series

Reports, 2020
Descemet’s membrane detachment (DMD) is an uncommon, vision-threatening, ocular surface complication of cataract surgery. Among several treatment strategies, sulfur hexafluoride (SF6) descemetopexy is the standard of care.
Heng-Chiao Huang, Ren-Long Jan, Sung-Huei Tseng, Chia-Yi Lee, Fu-Tsung Wei, Yuh-Shin Chang   +5 more
doaj   +1 more source

High throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells. [PDF]

PLoS ONE, 2013
Considerable interest has been generated for the development of suitable corneal endothelial graft alternatives through cell-tissue engineering, which can potentially alleviate the shortage of corneal transplant material.
Zhenzhi Chng, Gary S L Peh, Wishva B Herath, Terence Y D Cheng, Heng-Pei Ang, Kah-Peng Toh, Paul Robson, Jodhbir S Mehta, Alan Colman   +8 more
doaj   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Generation of a Novel Col8a2P2A‐CreERT2 Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation

genesis, Volume 64, Issue 2, April 2026.
ABSTRACT The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage‐specific genetic driver.
Yong Yuan, Josiah Holt, Samuel Lorry, Yen‐Chiao Wang, Yueh‐Chiang Hu, Zhixing Ma, Adam Kaufman, Winston Kao, Diego G. Ogando, Chia‐Yang Liu   +9 more
wiley   +1 more source