Results 81 to 90 of about 2,270,919 (288)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

UKESM1: Description and Evaluation of the U.K. Earth System Model

open access: yesJournal of Advances in Modeling Earth Systems, 2019
We document the development of the first version of the U.K. Earth System Model UKESM1. The model represents a major advance on its predecessor HadGEM2‐ES, with enhancements to all component models and new feedback mechanisms.
A. Sellar   +48 more
semanticscholar   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Authentic collections of Myriostoma calongei revealed this species as occurring from Paraíba State, Brazil

open access: yesHoehnea
Myriostoma is a gasteroid genus belonging to the order Geastrales, which is distinguished by its basidiomes with multiple columns/pedicels, several ostioles in its endoperidium, and predominantly subglobose basidiospores with ornamentation.
Isabella Silva Miranda   +3 more
doaj   +1 more source

Lecture, intertextualité et comique: Des Esseintes voyage

open access: yesLingue e Linguaggi, 2013
ENHuysmans has tried, with À rebours, to put into practice his will of renewal of the novel. In this perspective, he has used the resources of intertextuality in order to distance himself from what he calls “le roman romanesque”.
R. S. Monsegu
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Editorial: “Anything goes?”

open access: yesThe European Journal of Humour Research, 2015
Editorial: “Anything goes?”Editorial: “Anything Goes?”
Mike Lloyd
doaj  

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