Results 211 to 220 of about 1,076,775 (291)

CRISPR/Cas13a: Compensatory Target Activation Mechanism

open access: yesAdvanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang   +8 more
wiley   +1 more source

Current‐Driven Nonreciprocal Response of Nonequilibrium Skyrmions

open access: yesAdvanced Science, EarlyView.
A skyrmion holds great promise for spintronic applications owing to its intrinsic topological stability and high mobility under ultra‐low current excitation. Here, by means of in situ electron microscopy, we demonstrate a skyrmion diode effect and the associated current‐driven nonreciprocal skyrmion dynamics in a designed FeGe‐based microdevice.
Xiuzhen Yu   +10 more
wiley   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

open access: yesAdvanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

open access: yesAdvanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li   +8 more
wiley   +1 more source

Exploring stakeholder perceptions of peer support initiatives in the management of diabetes in low- and middle-income countries: An online survey study. [PDF]

open access: yesPLOS Glob Public Health
Gyawali B   +8 more
europepmc   +1 more source

Modulating Persistent Photoconductivity through Barrier Engineering for High‐performance and Multifunctional Two‐dimensional Optoelectronic Devices

open access: yesAdvanced Science, EarlyView.
Schottky barrier engineering using van der Waals contacts enables effective modulation of persistent photoconductivity (PPC) in optoelectronic devices. A high persistent photoconductivity gain (PPCG) (307.6%) is achieved in a high‐barrier Au/MoS2 junction, supporting photomemory and optoelectronic synaptic behaviors. A low PPCG (4.72%) is achieved in a
Panpan Huo   +8 more
wiley   +1 more source

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