Results 281 to 290 of about 16,858,520 (353)
Magnetic structure determination and refinement using FullProf. [PDF]
Rodriguez-Carvajal J+2 more
europepmc +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Outcomes of lung transplantation for end stage lung disease with connective tissue disease: a systematic review and meta-analysis. [PDF]
Liu J+6 more
europepmc +1 more source
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Mobilizing primary biodiversity records in environmental assessments in Spain. [PDF]
Telletxea M+3 more
europepmc +1 more source
A physical description of a variable-Mach-number 4- by 4-inch pilot corner nozzle [PDF]
Hans Peter Liepman+2 more
openalex
Erratum: See correct description of Cover art for Volume 112, Number 2, March-April 2007.
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source