Results 91 to 100 of about 37,653 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Description of a sigma-coordinate ocean model

, 1996
De siste årene har en havmodell basert på Blumberg og Mellors ECOM3D blitt benyttet ved Havforskningsinstituttet. Dette er en populær modell som blir benyttet ved en rekke institusjoner både nasjonalt og internasjonalt. Basert på de erfaringene en har gjort er det imidlertid mulig å peke på flere svakheter ved modellen.
Berntsen, Jarle, Skogen, Morten D., Espelid, Terje O.   +2 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Intestinal microbiota development in the first week of life of preterm newborns

Jornal de Pediatria
Objective: This study aimed to evaluate the intestinal microbiota development in the first week of life of preterm newborns (PTNB) treated at a public hospital in a municipality in the Brazilian Northeast. Methods: This is an observational, longitudinal,
Jessica Santos Passos Costa, Heli Vieira Brandão, Camilla da Cruz Martins, Raquel Guimarães Benevides, Jean Carlos Zambrano Contreras, Luiz Gustavo Sparvoli, Pedro Augusto Ramos Vanzele, Carla Romano Taddei, Tatiana de Oliveira Vieira, Graciete Oliveira Vieira   +9 more
doaj   +1 more source

An explicit description in terms of Plücker coordinates of the Langrangian-Grassmannian

, 2016
19 ...
Carrillo-Pacheco, J., Jarquín-Zárate, F., Velasco-Fuentes, M., Zaldívar, F.   +3 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

BAAC: A Prolog System for Action Description and Agents Coordination.

, 2011
The paper presents a system for knowledge representation and coordination, where autonomous agents reason and act in a shared environment. Agents autonomously pursue individual goals, but can interact through a shared knowledge repository. In their interactions, agents deal with problems of synchronization and concurrency, and have to realize ...
DOVIER, Agostino, ANDREA FORMISANO, ENRICO PONTELLI   +2 more
openaire   +3 more sources