Results 141 to 150 of about 676,729 (295)

Describe or Direct? Artificial Intelligence Explanation Type, Trust and User Behaviour in a Medical Imaging Rostering Task. [PDF]

J Med Radiat Sci
O'Callahan K, Sitters S, O'Callahan M, Senior-Partridge A, Kirtley M.   +4 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Structural characteristics of research ethics committees in Japan and their relevance to regulatory science: a nationwide descriptive study

Hara Tomohiko, Yuki Iwahara, Shunsaku Murakawa   +2 more
openalex   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Description of Ethics Requirements

Project management has to ensure that all ethics issues related to activities in the grant are addressed in compliance with ethical principles the applicable international and national law and the provisions set out in the Grant Agreement This deliverable will present the specific ethically relevant aspects and requirements of this project in ...
openaire   +1 more source

Additional file 1 of Structural characteristics of research ethics committees in Japan and their relevance to regulatory science: a nationwide descriptive study

Tomohiko Hara, Yuki Iwahara, Shunsaku Murakawa   +2 more
openalex   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Association Between Surgical Timing and In-Hospital Mortality in Infective Endocarditis: A Retrospective Single-Centre Study. [PDF]

Antibiotics (Basel)
Radu AM, Talpoși IF, Țoțoiu RE, Berbecaru RO, Dobrin A, Melinte V, Văcăroiu CM, Holban T, Popa MC, Călinoiu A, Popa OA, Iancu ME, Tomescu L, Săndulescu O, Gheorghiță V.   +14 more
europepmc   +1 more source

Nurse Educators’ Perspectives in Facilitating Ethics Education: A Descriptive Qualitative Study [PDF]

Yusrita Zolkefli, Siti Hanna Muharram, Nursalam Nursalam, Ashikin Atan   +3 more
openalex   +1 more source