Results 21 to 30 of about 2,867,174 (290)

CONSIDERATIONS REGARDING THE EMOTIONAL FACTOR IN ERGONOMICS AND DESIGN

open access: yesJournal of Industrial Design and Engineering Graphics, 2015
Considering the quick development in technology, it is more and more necessary to place the problem of studying the effects of the emotions created, both in terms of design and ergonomics.
DUCA Mioara   +2 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

CONTRIBUTIONS FOR DEVELOPING OF A COMPUTER AIDED LEARNING ENVIRONMENT OF DESCRIPTIVE GEOMETRY

open access: yesJournal of Industrial Design and Engineering Graphics, 2009
The paper presents the authors’ contributions for developing a computer code for teaching of descriptive geometry using the computer aided learning techniques.
Antonescu Ion   +2 more
doaj  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

General Explicit Solution of Planar Weakly Delayed Linear Discrete Systems and Pasting Its Solutions

open access: yesAbstract and Applied Analysis, 2014
Planar linear discrete systems with constant coefficients and delays x(k+1)=Ax(k)+∑l=1n‍Blxl(k-ml) are considered where k∈ℤ0∞:={0,1,…,∞}, m1,m2,…,mn are constant integer delays ...
Josef Diblík, Hana Halfarová
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Descriptive geometry as a science [PDF]

open access: yes, 2021
В статье рассматриваются вопросы изучения начертательной геометрии. Особое внимание уделяется построению алгоритмов. Делается вывод о том, что методики изучения начертательной геометрии с помощью алгоритмов помогают познавательной деятельности ...
Лапко, О. А.   +1 more
core   +2 more sources

SIGNS LANGUAGE IN GRAPHICAL COMMUNICATION MECHANICAL DRAWING: THE BASIC LANGUAGE IN GRAPHICAL COMMUNICATION

open access: yesJournal of Industrial Design and Engineering Graphics, 2010
The paper presents general notions about graphical language used in engineering, the international standards used for representing objects and also the most important software applications used in Computer Aided Design for the development of products in ...
BADEA Florina, PETRESCU Ligia
doaj  

Representation of the Solutions of Linear Discrete Systems with Constant Coefficients and Two Delays

open access: yesAbstract and Applied Analysis, 2014
The purpose of this paper is to develop a method for the construction of solutions to initial problems of linear discrete systems with constant coefficients and with two delays Δx(k)=Bx(k-m)+Cx(k-n)+f(k), where m,n∈ℕ, m≠n, are fixed, k=0,…,∞, B=(bij), C=(
Josef Diblík, Blanka Morávková
doaj   +1 more source

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