Results 101 to 110 of about 18,823,771 (330)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Legal Research- Descriptive Analysis on Doctrinal Methodology

International Journal of Management, Technology, and Social Sciences, 2019
Human beings possess instinct of inquisitiveness in cases of confronting with the unknown aspects of life which probe to attain greater understanding on such uncertainty.
Pradeep M.D.
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The Retrieval Effectiveness of Web Search Engines: Considering Results Descriptions [PDF]

arXiv, 2015
Purpose: To compare five major Web search engines (Google, Yahoo, MSN, Ask.com, and Seekport) for their retrieval effectiveness, taking into account not only the results but also the results descriptions. Design/Methodology/Approach: The study uses real-life queries. Results are made anonymous and are randomised.
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Concepções de homens hospitalizados sobre a relação entre gênero e saúde

Psicologia: Teoria e Pesquisa
A saúde masculina é ainda pouco discutida. Estudos mostram que há um padrão social hegemônico sobre o masculino que influencia comportamentos preventivos de homens diante da saúde.
Florêncio Mariano da Costa-Júnior, Ana Cláudia Bortolozzi Maia   +1 more
doaj   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

A COMPARATIVE STUDY ON INTROVERT AND EXTROVERT STUDENTS PERSONALITY IN ENGLISH LISTENING SCORES

Journal of English Education and Teaching, 2018
The objectives of this research were to investigate whether there were any significant differences between introvert and extrovert students on their listening score and to find out which of the students who have better in English listening scores.
Yessi Travolta, Mulyadi ., Imranuddin .
doaj   +1 more source

Information retrieval in Current Research Information Systems [PDF]

arXiv, 2001
In this paper we describe the requirements for research information systems and problems which arise in the development of such system. Here is shown which problems could be solved by using of knowledge markup technologies. Ontology for Research Information System offered.
arxiv  

A Paradox Perspective on Corporate Sustainability: Descriptive, Instrumental, and Normative Aspects

, 2018
The last decade has witnessed the emergence of a paradox perspective on corporate sustainability. By explicitly acknowledging tensions between different desirable, yet interdependent and conflicting sustainability objectives, a paradox perspective ...
Tobias Hahn, F. Figge, J. Pinkse, Lutz Preuss   +3 more
semanticscholar   +1 more source